Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections.Chitosan polyelectrolyte complex...

Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections.Chitosan polyelectrolyte complex...

Adsorbed layers of polyelectrolytes have been studied with atomic force microscopy (AFM) and the interferometric surface force apparatus (SFA). Particular emphasis was put on determining the effect of the polyelectrolyte charge density on surface topography, and the effect of the polyelectrolyte coating on the adhesive properties. The AFM was employed to image individual polymer chains at low a...

     Among the numerous nanosized drug delivery systems currently under investigation, carbon nanotubes (CNTs), regardless of being single or multiple-walled, offer several advantages and are considered as promising candidates for drug targeting. Despite the valuable potentials of CNTs in drug delivery, their toxicity still remains an important issue. After the PEGylation of single-walled CNTs ...

Polystyrene-poly(acrylic acid)/poly(allylamine hydrochloride) polyelectrolyte multilayer was found to be instable and apt to reconstruct in the pure water. By depositing polystyrene-poly(acrylic acid)/poly(allylamine hydrochloride) multilayer on the polystyrene-poly(acrylic acid) hybrid CaCO(3) templates, novel polyelectrolyte capsules could be prepared after the removal of the templates. The r...

The mechanism of action of T4-induced polynu-cleotide kinase on short single-stranded deoxyoligonucleotideshas been investigated.It was found that the phosphorylationreaction catalyzed by T, polynucleotide kinase could be re-versed. Thus, a 5 ’-3*P-labeleddeoxyoligonucleotide and ADPon incubation with the enzyme formed [Y-~~PJATP.In addi-tion some radioac...

Polyelectrolytes are polymers carrying either positively or negatively charged ionizable groups. The properties of these polymers in solutions and at charged surfaces depend on the fraction of dissociated ionic groups, solvent quality for polymer backbone, solution dielectric constant, salt concentration, and polymer–substrate interactions. In this review, we summarize the current development o...

Two structurally similar bis-phenanthridinium–adenine conjugates (equipped with one or two adenines, respectively), exhibiting strong ds-DNA/RNA groove binding, revealed ratiometric fluorescent recognition of alternating AT-DNA with respect to other ds-DNA/RNA and ss-RNA. Further, CD spectra pattern of adenine–bis-phenanthridinium conjugate/polynucleotide complexes strongly depended on polynucl...

In this work, we consider the motion of a polaron in polynucleotide Holstein molecular chain constant electric field. It is shown that character depends not only on chosen parameters chain, but also initial distribution charge along chain. for small set value field intensity and fixed values parameters, changing it possible to observe either uniform movement or an oscillatory mode movement.