BACKGROUND Calmodulin (CaM) mutations have been identified recently in subjects with congenital long QT syndrome (LQTS) or catecholaminergic polymorphic ventricular tachycardia (CPVT), but the mechanisms responsible for these divergent arrhythmia-susceptibility syndromes in this context are unknown. We tested the hypothesis that LQTS-associated CaM mutants disrupt Ca2+ homeostasis in developing...

BACKGROUND Sudden arrhythmic death syndrome defines a sudden unexpected and unexplained death despite comprehensive pathological and toxicological investigation. Previous studies have focused on evaluation of adult relatives. There is, however, a lack of data in children, leading to highly variable management. We sought to determine the clinical utility of cardiac evaluation in pediatric relati...

Digoxin is rarely used in modern cardiovascular disease management. Therefore, digoxin toxicity has been infrequently encountered and it paramount to diagnose a timely fashion. Bidirectional ventricular tachycardia an unusual arrhythmia wherein every other beat different QRS axis as travels alternately down conduction pathways. The can be manifestation of myocarditis, myocardial infarct, Anders...

Mutations in ryanodine receptor 2 (RYR2) gene can cause catecholaminergic polymorphic ventricular tachycardia (CPVT). The novel RYR2-S4153R mutation has been implicated as a cause of CPVT and atrial fibrillation. The mutation has been functionally characterized via store-overload-induced Ca(2+) release (SOICR) and tritium-labelled ryanodine ([(3)H]ryanodine) binding assays. The S4153R mutation ...

conclusions diagnosis of tachycardia-induced cardiomyopathy in children is important, since appropriate treatment improves the prognosis. every child with recurrent and persistent palpitation with the first episode of congestive heart failure should be evaluated for tachycardia- induced cardiomyopathy. introduction tachycardia-induced cardiomyopathy (tic) is a ventricular dysfunction secondary ...

Background:Cardiovascular effects of acute organophosphate (OP) poisoning are common. This study was aimed to assess the cardiovascular effects of OP poisoned patients in Nepal. Methods:This was a prospective hospital-based cross-sectional study of 115 acute OP poisoned patients presenting in emergency department of a tertiary care teaching hospital of central Nepal during November 2008 to Octo...

Les signes clectrocardiographiques classiques nc sont pas toujours suMisants pour ·le diagnostic de la tachycardie ventriculaire. Nous avons insiste d'une part sur !'importance diagnostique des complex de ca· ptures et d'auters part sur l'import.anre des procedcs nouveux Tels :  1- Enrcgishemcnt du potentiel du faisreau de  2- Stimulation references endocavitaire.

conclusions echocardiography and 2d speckle tracking strain imaging shows improvements in left ventricular deformation indices in atrioventricular reentrant tachycardia (avrt) and atrioventricular nodal reentrant tachycardia (avnrt) patients for the mean systolic strain and strain rate at 24 hours and the three-month follow-up. in spite of the normal lvef, even during sinus rhythm, deformation ...