The aim of this study was to investigate the long-term clinical outcomes of valgus osteotomy combined with intramedullary nail for the treatment of shepherd’s crook deformity of polyostotic fibrous dysplasia. We reviewed the clinical data of 22 patients with polyostotic fibrous dysplasia that was treated at our department between January 1995 and January 2010. All 22 of the patients (23 femurs)...

Intramedullary osteosclerosis, a rare entity, is usually diagnosed after the exclusion of more sinister etiologies. It typically affects the lower extremity and is more common in females. While the lesion may be discovered incidentally during imaging, presenting symptoms may include pain in the affected bone that is exacerbated with physical activity. Laboratory values are normal, and the lesio...

Many studies have been made in the past in an effort to understand the pathogenetic factors that are involved in the development of fibrous dysplasia and McCune-Albright syndrome. Recently, with the aid of cellular and molecular biology, the implication of G protein mutations have been demonstrated to be a crucial etiopathogenetic factor for the manifestations of these disorders. In this paper,...

Melorheostosis is an atypical sclerosing bone dysplasia also known as "candle disease," "melting wax syndrome," or "Leri with incidence rate of less than one in every million. The diagnosis usually made by the radiographic appearance "dripping candle wax" on affected cortex. We describe case a 35-year-old male patient who presented long history different joint swelling, notably small joints rig...

A most unusual family with aggressive Paget's disease is reported. Three brothers out of 10 siblings developed the disease at a relatively early age. Two of these brothers developed an osteosarcoma and died. It is emphasized that very little information is available concerning the predisposition to severe polyostotic disease and even sarcomatous change when Paget's disease begins at a young age...