TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: Sodium oxybate is an effective treatment for multiple narcolepsy symptoms, including cataplexy. Currently approved formulations require twice-nightly dosing. Efficacy and safety of FT218, investigational, extended-release formulation once-nightly sodium (ON-SXB), were analyzed in adults with the REST-ON clinical trial (NCT02720744). ...

Background During the last 15 years, gabapentin has become an established component of postoperative pain treatment. Gabapentin has been employed in a wide range of doses, but little is known about the optimal dose, providing the best balance between benefit and harm. This systematic review with meta-analyses aimed to explore the beneficial and harmful effects of various doses of gabapentin adm...

There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as wel...