Cyclooxygenases (COX)-1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process. COX-2 isoform has been predominantly explored as the most suitable target for pharmacological intervention in epilepsy studies, while COX-1 remains ...

Song, Juan and Mark A. Tanouye. Seizure suppression by shakB, a gap junction mutation in Drosophila. J Neurophysiol 95: 627–635, 2006. First published September 28, 2005; doi:10.1152/jn.01059.2004. Gap junction proteins mediate electrical synaptic transmission. In Drosophila, flies carrying null mutations in the shakB locus, such as shakB, have behavioral and electrophysiological defects in the...

OBJECTIVE Increases in accumulated energy on intracranial EEG are associated with oncoming seizures in retrospective studies, supporting the idea that seizures are generated over time. Published seizure prediction methods require comparison to 'baseline' data, sleep staging, and selecting seizures that are not clustered closely in time. In this study, we attempt to remove these constraints by u...

Epilepsy is a debilitating and potentially life-threatening neurological condition which affects approximately 65 million people worldwide. There currently no reliable simple early warning seizure-onset device available, means many with unstable epilepsy live in fear of injury or sudden death the negative impact social stigmatization. If anecdotal claims that untrained dogs anticipate seizures ...

PURPOSE Resective epilepsy surgery is the recommended treatment for a well-defined group of patients with drug-resistant epilepsy. Long-term outcome studies are an appropriate quality control to assess the value of elective surgical procedures ethically and economically. This paper reports the long-term post-surgical follow-up of adult patients of the Kork Epilepsy Centre. METHOD Data collect...

PURPOSE Status epilepticus has been increasingly associated with cardiac injury in both clinical and animal studies. Our group has previously shown that excitotoxic seizure induction results in the formation of ischaemic myocardial infarcts and loss of cardiac haemodynamic function. We hypothesised that attenuation of cardiac sympathetic/parasympathetic balance with a central presynaptic α₂ ago...

Objective.Local cooling of the brain as a therapeutic intervention is promising alternative for patients with epilepsy who do not respond to medication.In vitroandin vivostudies have demonstrated seizure-suppressing effect local in various animal models. In our work, focal bicuculline induced model rats and evaluated using multimodal micro-electrocorticography (microECoG) device.Approach.We des...

BACKGROUND Electroconvulsive therapy (ECT) is a highly effective and established treatment for depression. Magnetic seizure therapy (MST) has recently been developed and seems equally effective while associated with fewer side-effects. Both require general anaesthesia, which could be quantified using the bispectral index (BIS). We compared ECT and MST with respect to recovery times, left-sided ...

PURPOSE To review the clinical and neurophysiological data of 21 patients with epilepsy due to temporal lobe tumors and who had undergone evaluation and surgery at the Hospital das Clínicas da Universidade de São Paulo. The aim of this study was to investigate whether the occurrence of a mirror focus was influenced either by certain clinical factors or if the surgical outcome was influenced by ...

Radiotherapy has shown some efficacy for epilepsies but the insufficient confinement of the radiation dose to the pathological target reduces its indications. Synchrotron-generated X-rays overcome this limitation and allow the delivery of focalized radiation doses to discrete brain volumes via interlaced arrays of microbeams (IntMRT). Here, we used IntMRT to target brain structures involved in ...