The increasing demands for personalized targeted therapy directed against renal cell carcinoma have driven a search predictive markers. Novel therapies targeting HIF-1α in been developed, and has suggested as novel marker of response to therapy. surgical resection kidney tumor induces tissue ischemia, is an oxygen-sensitive transcription factor, which known be upregulated during hypoxia. This s...

OBJECTIVE During the past two decades, professional associations, accrediting bodies, and payors have made post-surgical pain treatment a high priority. In light of the disappointing findings in previous surveys, a survey was conducted to assess patient perceptions and characterize patient experiences/levels of satisfaction with post-surgical pain management. RESEARCH DESIGN AND METHODS Surve...

background and aims. the surgical removal of the lower third molars is a procedure generally followed by side effects such as postoperative pain. the aim of this study was to evaluate the efficacy of socket irrigation with an anesthetic solution in relieving pain following impacted third molar surgery. materials and methods. thirty-four patients (17 males and 17 females), aged 18-24 years, with...

This study examined pre-surgical depressed mood as a predictor of post-surgical memory change in adults who underwent temporal lobe resections (TLRs; n = 211). Patients completed the Wechsler Memory Scale-III and Beck Depression Inventory-Second Edition (BDI-II) before and after TLR (left = 110, right = 101) and were divided into two groups (clinically elevated depressive symptoms or not depres...

Development of treatments for acute and chronic pain conditions remains a challenge, with an unmet need for improved sensitivity and reproducibility in measuring pain in patients. Here we used pulsed-continuous arterial spin-labelling [pCASL], a relatively novel perfusion magnetic-resonance imaging technique, in conjunction with a commonly-used post-surgical model, to measure changes in regiona...

Post operative wound infection is considered as a surgeon’s nightmare. Before the mid 19 century, surgical patients commonly developed post operative purulent discharge from their incisions, followed by overwhelming sepsis, and often death. It was not until the late 1860s, after Joseph Lister introduced the principles of antisepsis that postoperative infections morbidity decreased substantially...

BACKGROUND Surgical removal of mandibular third molars results in some degree of post-operative pain, swelling and trismus. These can be controlled by proper administration of local anesthesia, careful bone removal, minimal trauma to adjacent soft tissues and administration of methylprednisolone and serratiopeptidase drugs. The aim of the present study was to compare the efficacy of methylpredn...

Local anesthetic infiltration prior to surgical incision closure is a frequently used technique in the operating room. Debate continues, with clinicians, as to the effectiveness of this technique in pain reduction. A literature review using PubMed with the criteria of "local anesthetic infiltration and pain reduction" was conducted for the use of local anesthetic infiltration prior to surgical ...