Polygonatum sibiricum polysaccharide (PSP) is a traditional Chinese medicine and is widely used to treat many diseases for hundreds of years conventionally. This study was to access the effects of PSP on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in the mice. Cells collected from BALB/C mice in the bone marrow were isolated and cultured with osteogenic medium (...

The sex sorting of spermatozoa by flow cytometry induces damage, since sperm cells are highly diluted, affecting their functionality and fertilizing ability. In this work it was investigated whether the concentration of sex sorted spermatozoa by the sedimentation method, rather than centrifugation, in combination with the presence of the seminal plasma protein PSP-I/PSP-II heterodimer may impro...

Neurexins (NRXNs) are presynaptic terminal proteins and candidate neurodevelopmental disorder susceptibility genes; mutations presumably upset synaptic stabilization and function. However, analysis of human cortical tissue samples by RNAseq and quantitative real-time PCR at 8-12 postconceptional weeks, prior to extensive synapse formation, showed expression of all three NRXNs as well as several...

In somatosensory cortex (S1) tactile stimulation activates specific regions. The borders between representations of different body parts constrain the spread of excitation and inhibition: connections that cross from one representation to another (cross-border, CB) are weaker than those remaining within the representation (noncross border, NCB). Thus, physiological properties of CB and NCB synap...

(a) GABA-evoked currents recorded in a P6 Purkinje cell using gramicidin perforated-patch recordings (see Supplementary Methods). Example traces at different holding potentials are superimposed (top), with the respective peak GABA-evoked current amplitudes plotted below. Scale bar, 50 pA, 100 ms. (b) GABA-evoked currents recorded in a P36 Purkinje cell. Scale bar, 50 pA, 100 ms. (c) The GABA re...

In a previous paper (Rudolph & Destexhe, 2006), we proposed various models, the gIF neuron models, of analytical integrate-and-fire (IF) neurons with conductance-based (COBA) dynamics for use in event-driven simulations. These models are based on an analytical approximation of the differential equation describing the IF neuron with exponential synaptic conductances and were successfully tested ...

espanolIntroduccion y objetivos: La escala de puntuacion PSP (pre-dilation, sizing and post-dilation), derivada del registro GHOST-EU, evalua la relacion entre tecnica implante los armazones bioabsorbibles resultados clinicos. El objetivo fue realizar una validacion externa determinar su efecto en eventos adversos cardiacos diversos escenarios clinicos anatomicos. Metodos: Para se emplearon dat...

The fast development of brain-inspired neuromorphic computing systems has stimulated urgent requirements for artificial synapses with low-power consumption. In this work, a photonic synaptic device based on (Al,Ga)N nanowire/graphene heterojunction been proposed and demonstrated successfully. the device, incident light, heterojunction, light-generated carriers play roles action potential, pre-s...

In somatosensory cortex (S1) tactile stimulation activates specific regions. The borders between representations of different body parts constrain the spread of excitation and inhibition: connections that cross from one representation to another (cross-border, CB) are weaker than those remaining within the representation (noncross border, NCB). Thus, physiological properties of CB and NCB synap...