Background: Posotoprative nausea and vomiting remains a persistent and distressing problem inspite of many advances on perioperative care and anti-emetic drugs. A newer antiemetic drug Granisetron has not been studied in patients undergoing gynaecological surgery under spinal anaesthesia. Objective: A randomized double blind study was conducted to compare Ondansetron and Granisetron for prevent...

BACKGROUND The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. METHODS A total of 320 patients scheduled for elective cardiac surgery were enrolled. Patients were randomly assigned to one of four treatment regimens (n=80 in each g...

Hypovolaemia after overnight fasting is believed to exacerbate postoperative nausea and vomiting (PONV). However, data on the efficacy of supplemental i.v. crystalloids for PONV prophylaxis are conflicting. We performed a literature search using CENTRAL, MEDLINE, EMBASE, CINAHL, and Web of Science. We included prospective randomized controlled trials that reported PONV event rates in patients r...

In a double-blind study, we have compared the prophylactic antiemetic effect of tropisetron 5 mg (Navoban, a 5-HT3 receptor antagonist) with that of placebo, both given as a short i.v. infusion approximately 15 min before wound closure in patients undergoing gynaecological surgery. Perioperative anaesthetic care was standardized and patients were observed for at least 24 h after operation. The ...

INTRODUCTION Post-operative nausea and vomiting (PONV) can impact recovery, with an average incidence of 38.3% (1). Predictors include: female gender, history of PONV, nonsmoker, perioperative opioids, and surgical procedure. Increases in intracranial pressure from Valsalva in craniotomies can result in tissue swelling, hemorrhage, or hematoma, compromising outcome (2). PONV the first 24 hours ...

PURPOSE This prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty. MATERIALS AND METHODS Sixty patients undergoing myringoplasty were sedated with midazolam in the presence of remifentanil (group MR), or after saline injection instead of remifentanil (group...

Post operative nausea and vomiting (PONV) remains an unpleasant and persistent problem for patients undergoing surgery. In fact PONV are among the most important factors contributing to delay in discharge of patients and an increase in unanticipated admissions after ambulatory surgery. Anesthesia providers are most often blamed for PONV, sometimes rightfully so, many times wrongly so. PONV is a...

BACKGROUND Although the use of postoperative opioids is a well-known risk factor for postoperative nausea and vomiting (PONV), few studies have been performed on the effects of intraoperative opioids on PONV. We examined the effects of a single bolus administration of fentanyl during anesthesia induction and the intraoperative infusion of remifentanil on PONV. METHODS Two hundred and fifty wo...

OBJECTIVE To evaluate attitudes of Chinese patients towards day-case surgery. DESIGN Prospective cross-sectional questionnaire survey. SETTING District public hospital, Hong Kong. PATIENTS Two hundred patients attending a preanaesthetic assessment clinic between 1 January and 30 June 2004 were invited to participate. MAIN OUTCOME MEASURES Demographic profiles, understanding and attitude...

BACKGROUND Several attempts have been made to evaluate patients' concerns with respect to postoperative recovery. To identify aspects of postoperative recovery relevant to patients, several methodological and statistical approaches have been used. One of the first to provide useful information was Fredrick Orkin who used conjoint analysis. This methodology is usually performed by market researc...