Cesium uptake by sodium-loaded frog sartorius muscles was inhibited 100% by 10(-6)M ouabain and 10(-6)M cymarin. The doses for 50% inhibition of cesium uptake by five cardiotonic aglycones were 1.5 x 10(-6)M for strophanthidin, 2 x 10(-7)M for telocinobufagin, 1.6 x 10(-6) for digitoxigenin, 2.4 x 10(-6)M for periplogenin, and 6.3 x 10(-6)M for uzarigenin. Because of the limited solubility of s...

THE ANTIEPILEPTIC ACTION OF DIPHENYLHYDANTOIN (DPH) HAS BEEN EXPLAINED BY TWO DIFFERENT THEORIES: (a) that DPH stimulates the Na-K pump; (b) that DPH specifically blocks the passive translocation of sodium. Since electrophysiological experiments have recently suggested abnormal synaptic mechanisms as the basis for epileptogenic discharges, the action of DPH on K transport within synaptic termin...

The kinetics of thallium exchange in cultured rat myocardial cells were studied and compared to those of potassium in the same tissue. Studies were carried out using low concentrations (10 nM to 5 microM) of thallium-204, approximating those likely to be encountered during clinical myocardial scintigraphy. Both thallium uptake and release could be described by a single exponential with a half-t...

as the basis for epileptogenic discharges, the action of DPH on K transport within synaptic terminals isolated from "normal" rat brain cortex was examined directly. A rapid filtration technique was used to assess in vitro potassium transport within synaptosomes. In vivo DPH did not significantly change endogenous K content within synaptosomes. With sodium (50 mM) and potassium (10 mM) concentra...

1. The "chloride space" in frog skin was determined and found to be 69.7 per cent by weight of wet skin. The chloride space occupies about 94 per cent of the total water space of skin. From this and other information, it appears that the "non-chloride space" measures only a part of the space occupied by the structural elements of skin. This space is referred to here as the intracellular compart...

the interaction between sodium and calcium, magnesium and calcium and the combined effect of sodium, magnesium and calcium was observed on the growth and ion uptake of hippophae rhamnoides l. the results demonstrated that an addition of sodium with calcium, (set a, na 2.5 + ca 5 mm) showed prominent increase in fresh weight of roots and shoots. the dry weight (average) of roots decreased and th...

The uptake of 'H-i-norepinephrine was examined in isolated perfused rat lungs, and the mechanism of uptake was compared with that previously found for 5-hydroxytryptamine. Most of the norepinephrine taken up by the lungs was rapidly deaminated and O-methylated, and the metabolic products were subsequently returned to the perfusate. The presence of iproniazid and tropolone markedly inhibited thi...