نتایج جستجو برای: pou1f1
تعداد نتایج: 147 فیلتر نتایج به سال:
The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression and GH regulation by Pit-1 have also been demonstrated in mammary gland. However, no data are available on the role of Pit-1 on breast PRL. To evaluate this role, several human breast cancer cell lines were transfected with either the Pit-1 expression vector or a Pit-1 small...
Temperament is fundamental to animal production due to its direct influence on the animal-herdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and...
PURPOSE Congenital hypopituitarism is caused by mutations in pituitary transcription factors involved in the development of the hypothalamic-pituitary axis. Mutation frequencies of genes involved in congenital hypopituitarism are extremely low and vary substantially between ethnicities. This study was undertaken to compare the clinical, endocrinological, and radiological features of patients wi...
صفت چندقلوزایی از جمله صفات آستانهای میباشد که بهوسیله ژنهای زیادی کنترل میشود. به دلیل وراثتپذیری پایین این صفت (حدود 10/0) استفاده از روشهای کلاسیک اصلاح نژاد، پیشرفت کندی دارد. بنابراین، نیاز به استفاده از فناوریهای جدید در بهبود این صفت میباشد. طول کروموزوم 1 بز حدود 186 سانتی مورگان میباشد. با توجه به تحقیقات پیشین و همولوژی بالای نقشه ژنومی گاو و بز، در این تحقیق منطقه بین 16 تا...
Prophet of POU1F1 (PROP1) plays direct or indirect important roles in the morphogenesis of pituitary gonadotropes as well as lactotropes, somatotropes and caudomedial thyrotropes. It also controls the expression of growth hormone, prolactin and thyrotropin subunits through regulatory PIT1 factor. These hormones have important influences on production traits in most animal species including the ...
OBJECTIVE Combined pituitary hormonal deficiency (CPHD) can result from mutations within genes that encode transcription factors. This study evaluated the frequency of mutations in these genes in a cohort of 144 unrelated Italian patients with CPHD and estimated the overall prevalence of mutations across different populations using a systematic literature review. MATERIAL AND METHODS A multic...
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