Purpose: To evaluate safety and tolerability on the ocular surface of an anti-septic formulation containing 0.6% povidone–iodine (0.6% PVI) for a 4 week period. Methods: An observational, prospecti...

BACKGROUND Whether oral antiseptics could reduce the risk of ventilator associated pneumonia (VAP) in patients receiving mechanical ventilation remains controversial. We performed a meta-analysis to assess the effect of oral care with antiseptics on the prevalence of ventilator associated pneumonia in adult critically ill patients. METHODS A comprehensive search of PubMed, Embase and Web of S...

BACKGROUND Chlorhexidine is better than povidone iodine for skin preparation before intravascular device insertion or blood culture collection, but it is not known whether chlorhexidine is superior in reducing colonization of continuous epidural catheters. METHODS Children requiring an epidural catheter for postoperative analgesia longer than 24 h were randomly assigned to receive skin prepar...

To the Editors:Your concerns regarding the recently published study, ‘‘A randomized trial that compared povidone iodine and chlorhexidine as antiseptics for vaginal hysterectomy,’’ are appreciated. First, by way of clarification, the literature search to which you refer did retrieve studies in which vaginal chlorhexidine had been used. In fact, we found 3 studies (including a total of more than...

background: infection control should be an integrated part of patient care, especially to ensure safety and survival in hospitalized neonates. although povidone‑iodine (pvp‑i) solution has been used as the most common antiseptic in hospitals of iran, chlorhexidine is currently used in some wards for skin disinfection. however, there is no evidence about the superiority of either antiseptic solu...

BACKGROUND Catheter-related infection is the third cause of infections in intensive care units (ICU), increasing the length of stay in ICU and hospital, mortality, and costs. Skin antisepsis is one of the most prevalent preventive measures. In this respect, it would appear preferable to recommend the use of alcoholic povidone iodine or chlorhexidine rather than aqueous povidone iodine. However,...

background and objectives: hand hygiene is a crucial measure for preventing healthcare-related infections. surgical scrub is an important factor in the safety and success of a surgical operation. the aim of this study was to comparatively evaluate effectiveness of some conventional surgical antiseptic solutions, and to identify the most effective one. methods: effectiveness of alcohol-based sol...

BACKGROUND Postoperative endophthalmitis is one the most serious complications of cataract surgery. The majority of causative organisms in this destructive infection come from the patient's own periocular flora. Efforts have been made to reduce the virulence of organisms in the eyelid and conjunctiva with perioperative topical antibiotics, preparation of surgical field, covering eyelids and con...

BACKGROUND Most of surgical site infections (SSI) are caused by commensal and pathogenic agents from the patient's microbiota, which may include antibiotic resistant strains. Pre-surgical asepsis of the skin is one of the preventive measures performed to reduce SSI incidence and also antibiotic resistance dissemination. However, in veterinary medicine there is no agreement on which biocide is t...

Colonization with health care-associated pathogens such as Staphylococcus aureus, enterococci, Gram-negative organisms, and Clostridium difficile is associated with increased risk of infection. Decolonization is an evidence-based intervention that can be used to prevent health care-associated infections (HAIs). This review evaluates agents used for nasal topical decolonization, topical (e.g., s...