Natural products are excellent resources for finding lead structures for the development of chemotherapeutic agents. Coumarins are a class of natural compounds found in a variety of plants. In this study, we evaluated the cytotoxic potential of coumarins isolated from Prangos ferulacea (L.) Lindl. in PC3, SKNMC, and H1299 (p53 null) human carcinoma cell lines. Osthole proved to be an outstandin...

The aim of this study was to compare chemical composition, relative feed values, and in vitro true digestibility the giant fennel (Ferula communicus L. -F), helis (Prangos ferulacea -H), gum- tragacanth (Astragalus microcephalus WILD. -G) leaves oak tree (Quercus robur -O), a naturally growing plant on high- altitude plateaus Eastern Anatolia, with those alfalfa. In digestibilities (IVTD) rough...

1. Trade-offs in an herbivore’s ability to feed, avoid predation and succeed on alternative hosts are thought to be major driving factors in host specialization. In this study, we compared how two closely related milkweed beetles (Tetraopes spp.) that have specialized on separate Asclepias species respond to host switching to alternative milkweed plants. By additionally examining effects on the...