one of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. however, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.the main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

objective: the purpose of this study was to evaluate the dental movements of the labial segment and the canines during leveling and alignment using pre-adjusted appliances and light forces with the mbt technique. the effect of lacebacks on the horizontal movement of the first molars was also assessed. materials and methods: fourteen patients with a mean age of 14.08 years were selected for this...

abstract background: abnormal uterine bleeding (aub) is one of the most common complains in women of any age seeking gynecologic health care and needs early diagnosis and proper management due to its impacts on the quality of life. this study was conducted to investigate the cut-off value of endometrial thickness (et) by trans-vaginal ultra-sonography (tvus) and evaluate its accuracy in the dia...

conclusions hbv in children due to vaccination failure was resulted from vertical transmission. hbv pre-s/s gene mutations were prevalent and could occur before or after vaccination. therefore, simply analyzing mutation frequency of hbv gene was not of value. to advance blocking hbv vertical transmission, future studies should focus on specific mutation sites, potentially associated with vaccin...

1 Department of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal 2 Institute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, Portugal 3 Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal 4 Center for Research in Health Technologies and Information Systems (CINTESIS), Faculty of Medicin...