exigencies of a country practice allowed. The case may be summarized as one of puerperal eclampsia with albuminuria? spontaneous and easy labour?recovery. The facts of the case merely are recorded, the pathology being avoided as somewhat dangerous ground. On the morning of Sunday, 18th August 1878, about 8 a.m., we received a note from a farmer living some five miles distant, asking us to see h...

An association between pre-eclampsia and febrile convulsions has been reported, but the association may not be causal. We compared the risk of febrile convulsions in 14 974 children who had been exposed to pre-eclampsia in fetal life with that of 39 210 unexposed children. Children exposed to pre-eclampsia had a slightly increased risk of febrile convulsions, but the association was apparently ...

BACKGROUND Women with a history of pre-eclampsia have a higher risk of developing pre-eclampsia in subsequent pregnancies. However, the role of the inter-pregnancy interval on this association is unclear. OBJECTIVE To explore the effect of inter-pregnancy interval on the risk of recurrent pre-eclampsia or eclampia. SEARCH STRATEGY MEDLINE, EMBASE and LILACS were searched (inception to July ...

conclusion: in this study group, tnf-α -238 polymorphism was shown to be different in preeclamptic and non-preeclamptic pregnant women. the aa genotype and the a allele may carry an increased risk for developing of preeclampsia. results: there were significant differences between the two groups in tnf-α genotype at position -238 (p < 0.001). in the preeclamptic group, the frequency of the aa ge...

OBJECTIVES To develop a predictive model for pre-eclampsia based on clinical risk factors for nulliparous women and to identify a subgroup at increased risk, in whom specialist referral might be indicated. DESIGN Prospective multicentre cohort. SETTING Five centres in Auckland, New Zealand; Adelaide, Australia; Manchester and London, United Kingdom; and Cork, Republic of Ireland. PARTICIP...

BACKGROUND Increased aldosterone concentrations and volume expansion of normal pregnancies are hallmarks of normal pregnancies and blunted in pre-eclampsia. Accordingly, we hypothesized an active mineralocorticoid system to protect from pre-eclampsia. METHODS In pregnant women (normotensive n = 44; pre-eclamptic n = 48), blood pressure, urinary tetrahydro-aldosterone excretion and activating ...

BACKGROUND Pre-eclampsia is a major contributor to maternal and neonatal morbidity and mortality. Our objectives in this study are to economically assess, from the payer perspective, routine screening for pre-eclampsia using placental markers -placental protein 13 and placental growth factor - and uterine artery Doppler compared with standard care. METHODS A decision model was developed, whic...

BACKGROUND Oxidative stress plays a role in the aetiology of pre-eclampsia and vitamin C may prevent pre-eclampsia. OBJECTIVE To determine the association between plasma vitamin C and pre-eclampsia in Mulago Hospital, Kampala, Uganda. METHODS This case-control study was conducted at Mulago Hospital from 1(st) May 2008 to 1(st) May 2009; 207 women were the cases and 352 women were the contro...

BACKGROUND Pre-eclampsia shares a number of risk factors with cardiovascular disease (CVD). Women with recurrent pre-eclampsia or pre-eclampsia early in pregnancy reportedly have an increased long-term risk of CVD. Short stature is a risk factor for CVD but has rarely been examined in relation to pre-eclampsia. METHODS We used data from 59 968 singleton live births in the Danish National Birt...