PURPOSE To date, mouse lacrimal gland epithelial cells have been cultured successfully but only in cases involving newborn mouse lacrimal glands. In this work, we attempted to cultivate and characterize adult mouse lacrimal gland epithelial cells. METHODS Lacrimal glands were removed from newborn mice (C57B/6) and isolated lacrimal gland epithelial cells were seeded onto tissue culture treate...

A gross anatomical study was made on the lacrimal apparatus in seventeen adult camels (4-10 years age), and three foetuses. The lacrimal gland is situated between the caudodorsal aspect of the eyeball and the supraorbital and frontal process of the frontal and zygomatic bones, respectively. The gland consists of two lobes, cranial and caudal. The excretory ducts were 3-4 in number, and opened i...

AIMS To prospectively evaluate the reliability and efficacy of a new treatment for the reconstruction of the lacrimal duct using a new histo-engineered material, xenogeneic (bovine) acellular dermal matrix. METHOD Five patients (five eyes) with partial or total absence of the lacrimal duct were included in the study. Four patients (four eyes) suffered from traumatic injuries to the lacrimal d...

Heparan sulfate (HS), an extensively sulfated glycosaminoglycan abundant on cell surface proteoglycans, regulates intercellular signaling through its binding to various growth factors and receptors. In the lacrimal gland, branching morphogenesis depends on the interaction of heparan sulfate with Fgf10Fgfr2b. To address if lacrimal gland development and FGF signaling depends on 2-O-sulfation of ...

Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctival and eyelid epithelia and produce secretions that lubricate and protect the ocular surface. Sox9 expression localizes to the presumptive conjunctival epithelium as early as E11.5 and is detected in the lacrimal and harderian glands as they form. Conditional deletion showed that Sox9 is required for the deve...

PURPOSE In previous work, lacrimal glands of female mice were shown to express an mRNA encoding pancreatic lipase-related protein 1 (PLRP1), a member of the triacylglycerol lipase family. To investigate the hypothesis that lacrimal glands express mRNAs encoding other lipolytic enzymes, the present study was conducted to look for triacylglycerol lipase-related mRNAs in the lacrimal glands of rab...

PURPOSE OF REVIEW The goal of this article is to offer an update on the treatment and prognosis of the most common epithelial tumors of the lacrimal gland, report on new pathological entities and offer a review of the classification of lacrimal gland tumors. RECENT FINDINGS Improvements have been made in the understanding of lacrimal gland lesions with the knowledge that lacrimal gland tumors...

Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctival and eyelid epithelia and produce secretions that lubricate and protect the ocular surface. Sox9 expression localizes to the presumptive conjunctival epithelium as early as E11.5 and is detected in the lacrimal and harderian glands as they form. Conditional deletion showed that Sox9 is required for the deve...

Lacrimal punctal agenesis is a rare cause of congenital epiphora and may occur in isolation or in combination with other lacrimal drainage anomalies such as pathologies of the canaliculus, lacrimal sac, and nasolacrimal duct. It rarely occurs in a familial manner. If diagnosed earlier, management of this condition may be as simple as a sharp opening or may necessitate more complex interventions...

PURPOSE. The lacrimal gland secretes water, electrolytes, and protein into the tear film. Decreased secretion from the lacrimal gland can lead to dry eye syndromes with deleterious effects on vision. Protein kinase C (PKC)plays a major role in cholinergicand 1-adrenergic–induced protein secretion from the lacrimal gland. This study was undertaken to determine whether activation of PKC alone wou...