abtract Cervical cancer is the fourth leadingcauseof cancer-relateddeath inwomenworldwide,with90%ofcases occurring in lowand middle-income countries (LMICs). There has been a global effort to increase access to affordable screening in these settings; however, a corresponding increase in availability of effective and inexpensive treatmentmodalities for ablating or excising precancerous lesions i...

The evidence that high-risk HPV infections cause cervical cancers has led to two new approaches for cervical cancer control: vaccination to prevent HPV infections, and HPV screening to detect and treat cervical precancerous lesions. Two vaccines are currently available: quadrivalent vaccine targeting oncogenic HPV types 16, 18, 6, and 11, and bivalent vaccine targeting HPV 16 and 18. Both vacci...

The role of the CCHCR1 (coiled-coil α-helical rod protein 1) protein in the cell is poorly understood. It is thought to be engaged in processes such as proliferation and differentiation of epithelial cells, tissue-specific gene transcription and steroidogenesis. It is supposed to participate in keratinocyte transformation. It has also been found that this protein interacts with the E2 protein o...

Infections with high-risk human papillomaviruses (HPV), mainly HPV type 16, can cause malignant transformation of the human cervical epithelium and the development of cervical cancer (CxCa). A rapid and precise diagnosis of the precancerous lesions by conventional cytology or HPV DNA tests remains difficult and often leads to overtreatment. We quantitatively analyzed the HPV16 transcriptome of ...

Objective: To access the accuracy of visual inspection methods for diagnosing cervical dysplasia. Methods: This cross-sectional study was carried out between 1st December 2016 and 30th April 2017. All cases positive to Visual Inspections with Acetic acid (VIA) or Lugol’s Iodine (VILI) as well macroscopic abnormal cervices, irrespective results inspection, had a colposcopy-directed biopsy. Resul...