PURPOSE To examine the impact of newly initiated pregabalin or duloxetine treatment on fibromyalgia (FM) patients' encounters with potential drug-drug interactions (DDIs), the health care cost and utilization consequences of those interactions, and the impact of treatment on opioid utilization. PATIENTS AND METHODS Subjects included those with an FM diagnosis, a pregabalin or duloxetine presc...

BACKGROUND Pregabalin is a well-accepted treatment option for patients with neuropathic pain. However, the therapeutic efficacy of pregabalin for reducing the incidence of spinal surgery to treat leg symptoms in patients with lumbar spinal stenosis remains unknown. The purpose of this study was to analyze the therapeutic efficacy of pregabalin for reducing the incidence of spinal surgery for le...

BACKGROUND Population mean changes are difficult to use in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration. A consensus group has defined what constitutes minimal, moderate, and substantial benefit based on pain intensity and Patient Global Impression of Change scores. METHODS We obtained individual patient data from four ...

Pregabalin is an anticonvulsant, structural analogue of Gamma Amino Butyric Acid (GABA) and very much efficient in the management neuropathic pain incisional injury. The aim this research to evaluate efficacy preoperative administration pregabalin on postoperative analgesic requirement subjects undergoing total abdominal hysterectomy under spinal anaesthesia. : A randomized, placebo-controlled ...

purpose: to evaluate the efficacy of pregabalin and gabapentin for post-photorefractive keratectomy (prk) pain relief. methods: 150 patients were divided into 3 groups. after undergoing prk; groups 1, 2, 3 received pregabalin 75 mg, gabapentin 300 mg, and placebo 3 times daily for 3 days, respectively. patients could take acetaminophen-codeine 300/10 mg tablets every 4 hours as needed. patients...

BACKGROUND Carbamazepine and pregabalin have proven effects against neuropathic pain. Carbamazepine blocks voltage-dependent Na(+) channels, whereas pregabalin blocks voltage-dependent Ca(2+) channels. The authors hypothesized that the co-administration of these drugs would synergistically reduce neuropathic pain. METHODS Neuropathic pain was induced by L5 nerve ligation in Sprague-Dawley rat...

STUDY OBJECTIVES To compare pregabalin versus placebo and pramipexole for reducing restless legs syndrome (RLS)-related sleep disturbance. DESIGN Randomized, double-blinded, crossover trial. SETTING Twenty-three US sleep centers. PARTICIPANTS Eighty-five individuals with moderate to severe idiopathic RLS and associated sleep disturbance. INTERVENTIONS Participants were randomized across...

INTRODUCTION Improvements are needed in the management of cancer-induced bone pain (CIBP). The objective of this study was to assess the efficacy and safety of pregabalin compared with placebo in the adjunctive treatment of patients with moderate to severe CIBP who were receiving opioids. METHODS In this randomized, double-blind, placebo-controlled, parallel-group, multicenter trial, 152 adul...