نتایج جستجو برای: preimplantation genetic screening
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BACKGROUND Although preimplantation genetic screening (PGS) is widely offered, there are contradictory reports on the clinical merit of this procedure. Any gain from embryo selection following aneuploidy screening must significantly outweigh the impact of the procedure. Variability of technical expertise in embryo biopsy, blastomere fixation, fluorescence in situ hybridization analysis, along w...
BACKGROUND Although chromosomal mosaicism in human preimplantation embryos has been described for almost two decades, its exact prevalence is still unknown. The prevalence of mosaicism is important in the context of preimplantation genetic screening in which the chromosomal status of an embryo is determined by the analysis of a single cell from that embryo. METHODS Here we report a systematic...
Preimplantation genetic screening is being scrutinized, as recent randomized clinical trials failed to observe the expected significant increase in live birth rates following fluorescence in situ hybridization (FISH)-based screening. Although these randomized clinical trials are criticized on their design, skills or premature stop, it is generally believed that well-designed and well-executed r...
Joyce Harper1,13, Karen Sermon2, Joep Geraedts3, Katerina Vesela4, Gary Harton5, Alan Thornhill6, Tugce Pehlivan7, Francesco Fiorentino8, Sioban SenGupta1, Christine de Die-Smulders9, Cristina Magli10, Celine Moutou11 and Leeanda Wilton12 UCL Centre for PGD, Institute for Women’s Health, University College London, 86-96 Chenies Mews, WC1E6HX London, UK; Department of Embryology and Genetics, Vr...
INTRODUCTION The Familial Amyloid Polyneuropathy, with the world's largest focus in Portugal, is recognized by the National Board of Assisted Reproductive Technologies as a serious disease eligible for Preimplantation Genetic Diagnosis. This study aims to determine the prevalence of the use of Preimplantation Genetic Diagnosis in FAP carriers followed in Unidade Clínica de Paramiloidose, Centro...
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