background: b vitamins deficiencies in humans and animals have been known for some time to induce pain and inflammation. these symptoms can be readily alleviated by appropriate administration of vitamins b. the aim of this study was to evaluate opioids requirements and hemodynamic variables and analgesic effect of b vitamins and b vitamins-diclofenac in general anesthesia and post-anesthesia ca...

Although cardiac hypertrophy has been the subject of intensive investigation, regression of hypertrophy has been significantly less studied, precluding large-scale analysis of the relationship between these processes. In the present study, using pharmacological models of cardiac hypertrophy in mice, expression profiling was performed with fragments of more than 4,000 genes to characterize and c...

Numerous studies, usually limited to male rodents, have reported an inverse relationship between the age of the animal and the activities of various multi-cytochrome P450-dependent drug-metabolizing enzymes. It has been suggested that the aging-induced decline in hepatic drug-metabolizing capacity is solely a male phenomenon. That is, whereas the levels of male-specific isoforms of P450 decline...

The case of a 32-year-old parturient with a quintuplet pregnancy is described. The pregnancy had been complicated by premature labour which was treated with ritodrine tocolysis. Betamethasone was administered to hasten fetal lung maturation. The ritodrine therapy was complicated with fluid overload and pulmonary oedema requiring intravenous diuretic treatment. The patient presented urgently for...

Premature or Prelabour Rupture Of Membranes is classically defined as the rupture of integrity of the fetal membranes before the onset of labour and resulting in leakage of amniotic fluid [1-4]. Pre-labour rupture of membranes without spontaneous uterine contractions complicate approximately 10 % of all pregnancies, out of which 80 % occurs at term [5]. The management of PROM at term remains a ...

AIMS This study examined the effects on intraocular pressure, pulse rate, and blood pressure of low dose intravenous sedation with propofol. METHODS Twenty adult patients who were scheduled to undergo cataract surgery were given a single intravenous bolus (0.98 (SEM 0.4) mg/kg) of propofol for sedation before administering the local anaesthetic for cataract surgery. A small intravenous dose o...

UNLABELLED The aim of this study was to compare hemodynamic responses to intubation and pin head-holder application in two groups of neurosurgical patients given oral clonidine (3 microg/kg) or oral temazepam (10-20 mg) 90 min before the induction of anesthesia. Fifty patients undergoing elective craniotomy were randomized to either group. Anesthesia was induced with i.v. propofol 1500 mg/h, fe...

Platelet-rich plasma (PRP) contains a mixture of growth factors that play an important role in wound and fracture healing. While PRP enhanced bone formation by autogenous cancellous bone grafts, its influence in combination with different bone substitutes remained unknown. This study evaluated the effect of PRP on osteogenic differentiation and ectopic bone formation of human mesenchymal stem c...

OBJECTIVE The aim of this study was to compare the effects of a ketamine-propofol mixture (ketofol) and propofol on intraocular pressure (IOP) and haemodynamics in elderly patients during anaesthetic management at each repeated measurement times. METHODS Forty elderly ASA I and II patients were divided into two random groups and received either propofol (1.5 mg kg(-1); group P, n=20) or ketof...