Stem cell-based regenerative therapy is a potential cellular therapeutic strategy for patients with incurable brain diseases. Embryonic neural stem cells (NSCs) represent an attractive cell source in regenerative medicine strategies in the treatment of diseased brains. Here, we assess the capability of intracerebral embryonic NSCs transplantation for C57BL/6J mice with presbycusis in vivo. Morp...

Altered cortical spectrotemporal processing with age-related hearing loss 1 2 Abbreviated Title: Cortical processing and presbycusis 3 4 Michael Trujillo and Khaleel Razak* 5 Graduate Neuroscience Program and Department of Psychology, University of California, 6 Riverside, CA-92521 7 8 *corresponding author 9 Dept. of Psychology 10 University of California 11 900, University Avenue, 12 Riversid...

The persistence of afferent activity at stimulus offset was examined in mice as a function of age (experiment 1) and noise level (experiment 2), using a procedure devised by von Bekesy to study the physiological decay of afferent activity. Noise offset was presented from 1 to 10 ms (the temporal gap) prior to an acoustic startle stimulus, with an abrupt edge or a linear ramp having the duration...

We investigated the association between cellular immunity and age-related hearing loss (ARHL) development using three CD4+ T cell fractions, namely, naturally occurring regulatory cells (Treg), interleukin 1 receptor type 2-expressing (I1R2), non-Treg non-I1R2 (nTnI) cells, which comprised Treg I1R2-deleted cells. Inoculation of nTnI fraction into a ARHL murine model, not only prevented degener...

OBJECTIVE To identify chromosomal regions that show evidence of linkage to age-associated hearing impairment (presbycusis) in humans. DESIGN We evaluated the genetic linkage between quantitative measures from audiometric examinations and markers from a genomewide scan in a population-based sample ascertained without respect to hearing status. PARTICIPANTS Audiometric examinations were condu...

UNLABELLED Hearing loss in the elderly is one of the most frequent chronic diseases. AIM to estimate the prevalence of hearing loss in a representative sample of elderly people (aged 65 or over) in the city of Rio de Janeiro. MATERIAL AND METHOD a prospective, cross-sectional population-based study with 238 elderly people aged 65 years or more (198 women and 40 men). RESULTS the prevalenc...

Despite the fact that disabling, age related hearing loss or presbycusis affects around 360 million people globally World Health Organisation, there is quite often a lengthy delay between the time an individual first notices that they are having hearing difficulties and when they actually seek help from a hearing professional [1]. So why is it that people take so long to accept that their heari...

Hearing loss is one of the most common chronic health conditions and has important implications for patient quality of life. However, hearing loss is substantially underdetected and undertreated. We present clinical cases to illustrate common situations in which primary care physicians may be called on to identify or to manage hearing loss. With the data reported in the companion scientific rev...