Apoptosis is characterised by a series of typical morphological features, such as shrinkage of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by neighbouring cells. This paper reviews the current knowledge on the molecular mechanisms of apoptosis as they relate to the morphologic hallmarks and their implications for the detection of apoptosis in cardiac tiss...

Background: Techniques of sperm preparation require centrifugation to separate spermatozoa from the seminal plasma. The centrifugation can induce damage to the spermatozoa and increase reactive oxygen species(ROS) productionspecially in leukospermic speciemens that are associated with impaired function and fertilizing capacity. However in ICSI, fertilization can occure with damage DNA sperm but...

Formation of transcription-induced R-loops poses a critical threat to genomic integrity throughout evolution. We have recently shown that the SR protein ASF/SF2 prevents R-loop formation in vertebrates by cotranscriptionally binding to nascent mRNA precursors to prevent their reassociation with template DNA. Here, we identify another RNA binding protein, RNPS1, that when overexpressed strongly ...

A comprehensive investigation was carried out to minimize the cost price of the rock fragmentation process including: drilling, blasting, secondary blasting and separating the large boulders (oversize rocks) while loading, until the optimized fragmentation, powder factor and ratio of burden (B) to blasthole diameter (?h) were achieved by doing several stages of drilling and blasting practically...

This exploratory qualitative case study analyzes the risks of misappropriation COVID-19 relief funds managed by public agencies in County Los Angeles. documents deviance, sources misbehavior, vulnerability factors and mitigation strategies place to prevent fraud corruption. Results indicate that loopholes benefits eligibility certification led massive levels fraud, internal infrastructure work ...

Introduction: The amount of expression of BAX and BCL-2 genes in infertile men’s sperm as well as its association with sperm parameters and DNA fragmentation index is an issue which has not been studied yet. In this research, it is assumed that up-regulation of BAX and downregulation of BCL-2 are directly associated with sperm DNA fragmentation. Methods: After obtaining semen samples from the ...

Urgent structural change is required in higher education to allow collaboration both within and across universities so that achieving a rapid sustainability transition can become the overarching main purpose of education, research work society. A review literature reveals fragmentation, caused by traditional hierarchical faculty disciplinary organisation, major obstacle such goals. Additionally...

a detailed analysis of the electron-impact-induced fragmentation of 5,8dithiaspiro (3.1) octane and s,9-dithiaspiro 6.5) nonane is presented. the tetradeuteri6-analog of the cyclic dithioketals is prepared as an aid in analysing the fragmentation patterns. it was readily seen that the nature of the fragmentation pathway was governed by the size of the ring containing the two sulfur atoms and th...

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