In previous papers, we presented data on studies on the anticancer activity of the vitamin D₃ analogs, named PRI-2191 and PRI-2205, in different cancer models. In this study, we showed the improved antiproliferative activity of a combination of imatinib mesylate (Gleevec, GV) and cytostatic agents in in vitro studies, when used with a third compound, namely PRI-2191, in an A549 human lung cance...

BACKGROUND Micro RNAs-371-372-373 (miRNAs-371-373), originating from the same pri-miRNA transcript, are reported to be upregulated in hepatocellular carcinoma (HCC) and to be related to the regulation of hepatitis B virus (HBV) infection. Our study investigated whether pri-miRNAs-371-373 polymorphisms are associated with the risk of HCC occurrence and HBV clearance. METHODS Genetic variations...

MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to A substitution present in the terminal loop of pri-mir-30c-1 in breast and gastric cancer patients had been previously described to result in increased levels of mature miRNA. Here, we report that this g...

Samodejno razpoznavanje (avtentikacija/identifikacija) obrazov predstavlja eno najaktivnejših raziskovalnih področij biometrije. Avtentikacija oz. identifikacija oseb z razpoznavanjem obrazov ponuja možen način povečanja varnosti pri različnih dejavnostih, (npr. pri elektronskem poslovanju na medmrežju, pri bančnih storitvah ali pri vstopu v določene prostore, stavbe in države). Ponuja univerza...

In conjunction with the Committee on the Global Financial System Working Group project on foreign direct investment in emerging market financial sectors, staff of the U.S. Federal Reserve examined the market for political risk insurance (PRI) and its use by financial institutions to mitigate emerging market risks. A series of meetings were undertaken in 2003 with U.S. commercial and investment ...

The physiological basis for the advantage of alternate partial root-zone irrigation (PRI) over common deficit irrigation (DI) in improving crop water use efficiency (WUE) remains largely elusive. Here leaf gas exchange characteristics and photosynthetic CO(2)-response and light-response curves for maize (Zea mays L.) leaves exposed to PRI and DI were analysed under three N-fertilization rates, ...

Povzetek. Razločevanje akustičnih signalov je tehnični problem, pri katerem poskušamo iz mešanice akustičnih signalov razločevati posamezne vire. Uspešno razločevanje akustičnih signalov omogoča razvoj raznolikih senzorskih sistemov za uporabo v medicinski tehniki, industrijski avtomatizaciji in tehniki zabavne elektronike. Znano je, da je razločevanje mešanic mogoče predvsem zaradi statistične...

The study aimed at evaluating the effects of calcitriol and of its analogues on the proliferation of TT and rMTC cells (human and rat line tumour cells originating from thyroid medullary carcinoma) and at examining the effects of the substances on the secretion of the principal hormones of the cells, calcitonin (CT) and calcitonin gene-related peptide (CGRP). Cells of thyroid medullary carcinom...

Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome (22q11.2DS), heterozygous deletion of DiGeorge critical region gene 8 (DGCR8) causes a processing deficiency, which contributes to abnormal brain development. The DGCR8 protein is the RNA-binding partner of Drosh...