Lennox–Gastaut syndrome is an epileptic encephalopathy with onset in childhood. The classical triad of diagnostic criteria well known: 1) presence various types refractory seizures (tonic, atypical absences, myoclonic, tonic/atonic drop attacks, generalized tonic-clonic, focal); 2) cognitive disorders frequent behavioral (not always evident by the beginning seizures); 3) generalized, slow (≤2.5...

A 16-year-old boy, with a history of juvenile myoclonic epilepsy, which had been treated with valproic acid since he was 9 years of age, presented with bilateral periorbital rash. His family had found him in a stupor state after groaning early the previous morning. The patient had a history of morning myoclonic seizures and absence seizures, but no history of generalized tonic-clonic seizures. ...

Seizure episodes associated with generalized tonic clonic or partial seizure disorder is a life style debilitating disease. Several drugs have been developed, which are in use to control seizure episodes include carbamazepine, ethosuximide, felbamate, lamotrigine and phenytoin (Das et al., 2012; Bialer et al., 2013). While a long list of drug exists, phenytoin is preferred drug of choice as it:...

A 58-year-old man was admitted after a generalized tonic-clonic seizure. The neurological examination was normal, except for bilateral periorbital, enoral and superior thoracic petechiae, which had only occurred after the seizure. The blood pressure, CT scan of the brain and routine laboratory were unremarkable. Seizure-related petechial rash is a rare finding that might be helpful for the diag...

OBJECTIVE To evaluate the efficacy or eventual side-effects of the association of lamotrigine and sodium valproate in the control of refractory epilepsies. METHOD A retrospective analysis of 37 children with a mean age of 12 years taking exclusively lamotrigine and sodium valproate. Efficacy of seizure control was considered satisfactory if there was a reduction in seizures>50% or total contr...

A 19 year old male, with no past medical history, presented to the emergency department with a witnessed episode of generalized tonic-clonic seizure. The seizure lasted approximately 7 minutes. The episode was associated with tongue biting, loss of urinary sphincter control and a prolonged postictal state. On recovery, the patient denied any previous seizures or a family history of seizure. His...

A 38-year-old man had postictal global aphasia after generalized tonic-clonic seizure, but recovered within 1 day. There was a focal increase in the signal intensity of the left frontoparietal sulci on fluid-attenuated inversion recovery magnetic resonance (MR) sequence 6 hours after the seizure, which disappeared 1 month later. The transient seizure-induced MR hyperintensity was possibly cause...

We analyzed surgical results of anterior callosotomy (AC) in 27 patients with intractable symptomatic generalized epilepsy or frontal lobe epilepsy. Excellent outcome (decrease in seizure frequency of greater than 80% or no seizure) was obtained in 59.3%, and 14.8% showed good outcome(decrease in seizure frequency of greater than 50%). There was no significant difference of the results between ...

objective neonates, for many reasons, are at particular risk for the development of seizures, which are a strong predictor of later morbidity and mortality in infants. we undertook this study to determine the incidence, etiologic distribution and neonatal seizure type in neonates with hospital admission over a period of 4 years. materials and methods this, a retrospective study of newborns admi...

BACKGROUND According to the literature, generalized seizure as a presenting sign of stroke is rare, and in the reported cases it was accompanied by a focal neurological deficit. Presentation of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very rare. METHODS We reported a patient with acute small ischemic atherothrombotic infarction associated with ...