In this paper, bending analysis of concentric and eccentric beam stiffened square and rectangular plate using the meshless collocation method has been investigated. For detecting the governing equations of plate and beams, Mindlin plate theory and Timoshenko beam theory have been used, respectively, with the stiffness matrices of the plate and the beams obtained separately. The stiffness matric...

The functional effects of bone and suture stiffness were considered here using finite element models representing three different theoretical phenotypes of an Alligator mississippiensis mandible. The models were loaded using force estimates derived from muscle architecture in dissected specimens, constrained at the 18th and 19th teeth in the upper jaw and 19th tooth of the lower jaw, as well as...

The stiffness of the extracellular matrix exerts powerful effects on cell proliferation and differentiation, but the mechanisms transducing matrix stiffness into cellular fate decisions remain poorly understood. Two widely reported responses to matrix stiffening are increases in actomyosin contractility and cell proliferation. To delineate their relationship, we modulated cytoskeletal tension i...

Extracellular matrices determine cellular fate decisions through the regulation of intracellular force and stress. Previous studies suggest that matrix stiffness and ligand anchorage cause distinct signaling effects. We show herein how defined noncovalent anchorage of adhesion ligands to elastic substrates allows for dissection of intracellular adhesion signaling pathways related to matrix stif...

Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood. Recent engineering technologies have developed powerful techniques to charac...

This article presents an analysis of free vibration of elastically supported Timoshenko beams by using the spectral element method. The governing partial differential equation is elaborated to formulate the spectral stiffness matrix. Effectively, the non classical end boundary conditions of the beam are the primordial task to calibrate the phenomenon of the Timoshenko beam-soil foundation inter...