The widespread use of drugs that bind diffusible vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (AMD). The pivotal ranibizumab and aflibercept registration trials featured monthly intravitreal injections for 12 months, during which visual acuities and macular edema rapidly improved for the first 3 months and modest gain...

OBJECTIVE To assess the efficacy and safety profiles of two different rituximab retreatment regimens in patients with RA. METHODS Four hundred and ninety-three RA patients with an inadequate response to MTX recruited into rituximab Phase II/III studies received further courses of open-label rituximab based on two approaches: (i) treatment to target (TT): patients assessed 24 weeks after each ...

INTRODUCTION Ranibizumab (Lucentis), a humanised antibody fragment that inhibits vascular endothelial growth factor (VEGF)-A, is widely used for the treatment of neovascular age-related macular degeneration (NV-AMD). The objective of this study was to compare the outcomes of two different treatment protocols: loading dose (LD) and pro re nata (PRN (as needed)) dosing schedule from baseline. M...

OBJECTIVES To explore global changes in the prescription of analgesic drugs over time in the international long-term care (LTC) population. DESIGN Systematic review. SETTING We included original research articles in English, published and unpublished, that included number of participants, country and year(s) of data collection, and prescription of analgesics (analgesics not otherwise specif...

Coordinated proliferation of lung cells is required for normal lung growth and differentiation. Chronic injury to developing lung may disrupt normal patterns of cell proliferation. To examine patterns of cell proliferation in injured developing lungs, we investigated premature baboons delivered at 125 days gestation (approximately 67% of term) and treated with oxygen and ventilation for 6, 14, ...

A large pertussis epidemic occurred between 2008 and 2010 in Japan. To investigate epidemic strains, we analyzed 33 Bordetella pertussis isolates from the epidemic period by sequencing virulence-associated genes (fim3, ptxP, ptxA, and prn) and performing multilocus variable-number tandem repeat analysis (MLVA), and compared these results with those of 101 isolates from non-epidemic, earlier and...

The purpose of this study was to establish norms of photogrammetric soft tissue profile analysis for Anatolian Turkish adults. Standardized right lateral facial photographs of 111 Anatolian Turks (64 females, 47 males) with class I skeletal pattern were taken. Age range was 21 to 40 years. Descriptive statistics for 8 angular measurements were computed. Male and female values were compared with...

One of the most important components of orthodontic diagnosis and treatment planning is the evaluation of the patient's soft tissue profile. The aim of this study was to develop angular photogrammetric standards for Class I Anatolian Turkish males and females. A random sample of 100 Turkish individuals (46 males and 54 females; ages 19-25 years) was obtained. The photographic set-up consisted o...

Pseudo Random Number’s (PRN’s) are required for many cryptographic applications. This paper proposes a new method for generating PRN’s using Layer Recurrent Neural Network (LRNN). The proposed technique generates PRN’s from the weight matrix obtained from the layer weights of the LRNN. The LRNN random number generator (RNG) uses a short keyword as a seed and generates a long sequence as a pseud...