gaining acceptance in pharmacological studies (1,2). Numerous studies have demonstrated the capability of microdialysis sampling in characterizing the behavior of exogenous compounds in tissues such as blood (3-6), muscle (7,8), solid tumor (9), adipose (7,10), liver (1113), and dermis (14-17). Of all the commercially available probe designs, the BAS linear tissue probe (F1) is especially suita...

JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon l...

the goal of this study was to compare the effect of heater probe thermocoagulation for massive bleeding of peptic ulcers with a control group. between march 1992 and august 1995 we used heater probe thermocoagulation endoscopically to treat 42 patients with active ugl bleeding or nonbleeding visible vessels at the base of ulcer craters within 2-3 hours of admission. we also selected 42 patients...

This study aims to evaluate the clinical value of PCR-fluorescent probes for detecting mutation gene associated with extensively drug-resistant tuberculosis (XDR-TB). The molecular species identification 900 sputum specimens was performed using polymerase chain reaction (PCR)–fluorescent probe. mutations drug resistance genes rpoB, katG, inhA, embB, rpsL, rrs, and gyrA were detected. convention...

Ultrasound probes are used in sonographic scanning and are commonly used as either surface probes or endocavitary probes. Surface probes are used on intact skin, such as the abdomen; they are considered noncritical and require at least low-level disinfection between patients. Endocavitary probes (eg, transvaginal, transrectal, or transesophageal probes) are considered semicritical because they ...