BACKGROUND The steroid hormone progesterone is indispensable for mammalian procreation by controlling key female reproductive events that range from ovulation to implantation, maintenance of pregnancy and breast development. In addition to activating the progesterone receptors (PRs)-B and -A, members of the superfamily of ligand-dependent transcription factors, progesterone also elicits a varie...

Progesterone, a key female sex hormone with pleiotropic functions in maintenance of pregnancy, has profound effects on regulation of immune responses. We report in this work a novel function of progesterone in regulation of naive cord blood (CB) fetal T cell differentiation into key T regulatory cell (Treg) subsets. Progesterone drives allogeneic activation-induced differentiation of CB naive, ...

OBJECTIVE To compare progesterone concentrations in serum and endometrial tissue from hysterectomy specimens after vaginal or intramuscular (IM) administration of progesterone gel. METHODS This was a randomized open study of 14 post-menopausal women undergoing transabdominal hysterectomies. Participants received either vaginal progesterone gel, 90 mg, or IM progesterone, 50 mg, at 8:00 AM and...

For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms. Nuclear PR-immunoreactivity (PR-IR) in gonadotropes, identified by dual immunofluorescenc...

background:   objective: the purpose of this study was to compare the predictive value of progesterone level on ivf success in women with infertility due to tubal factor or pcos.   materials and methods: in a stratified cohort study, we assigned 76 infertile women of 20-38 years old who referred to women hospital into two equal groups with fallopian tube factor infertility and pcos. we measured...

background: the purpose of the study was to evaluate the role of progesterone/ estradiol (p4/e2) ratio as a predictive tool for clinical pregnancy in art cycles with a premature progesterone rise of >1.5 ng/ml on the day of human chorionic gonadotropin (hcg) trigger. methods: retrospective analysis was done on 569 fresh embryo transfer cycles from january 2011 to december 2012 at the infertilit...

objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...

conclusions in summary, progesterone administration reduced serum icam-1, and whereby may attenuate blood brain barrier disruption, the latter needs further investigation for confirmation. results a reduction in the serum level of icam-1 was noticed in the progesterone group 24 hours after the injury (p < 0.05). there was no significant difference in the serum level of nse between the study gro...

The causes of imminent abortion are multi-factorial. The biggest causal factor is the low level of serum progesterone level. The lowest critical level of serum progesterone for survivability of pregnancy is 10 ng/ml. Eighty percent of patients experiencing abortion showed that their progesterone level was < 10 ng/ml. Patients who realized that their pregnancy would experience hemorrhage general...

With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signall...