Background: Hyperbilirubinemia in newborn is quite common. Phototherapy (PT) one of the most common noninvasive methods for treatment this hyperbilirubinemia. There are limited studies available on effect PT platelet count with contrasting results. So, study was conducted to determine phototherapy counts hyperbilirubinemic neonates tertiary care hospital. Methods: This a hospital based prospect...

Aim . To study new molecular genetic markers of Gilbert’s syndrome (GS). Materials and methods It was a case – control study. The GS group included 125 people (mean age 38.5 ± 11.9 years, 58.9% were men) with unconjugated hyperbilirubinemia; known causes hyperbilirubinemia excluded. (n = 323, mean 48.9 53.2% random sample individuals from the DNA bank participants HAPIEE MONICA projects. isolat...

BACKGROUND Today, Severe hyperbilirubinemia is the most common cause of neonatal readmissions. Identification of the cause of neonatal hyperbilirubinemia is useful in determining whether therapeutic interventions can prevent severe hyperbilirubinemia. OBJECTIVES We conducted this study to estimate the incidence of severe hyperbilirubinemia in Fars province and to determine the underlying caus...

Abstract Background Neonatal jaundice, also known as hyperbilirubinemia in term and preterm infants, is treated with phototherapy when bilirubin results exceed gestational age- age-specific medical decision levels (MDL) to prevent kernicterus bilirubin-induced neurological damage. During phototherapy, unconjugated converted water-soluble isomers that are excreted the urine. Presently, electroni...

Crigler-Najjar Syndrome type II (CNS-II) is an autosomal recessive hereditary condition of unconjugated hyperbilirubinemia without hemolysis, with bilirubin levels ranging from 102.6 μmol/L to 342 μmol/L. CNS-II is caused by a deficiency of UDP-glucuronyl transferase (UGT), which is encoded by the UDP-glucuronyl transferase 1A1 gene (UGT1A1). In East Asian populations, the compound homozygous U...