There is no universal training curriculum for Physical and Rehabilitation Medicine (PRM) physicians. While PRM claims no organ system or tissue impairment, it specializes in maximizing function. It is imperative that we train excellent physicians who are experts in the evaluation of the nervous and musculoskeletal systems. However, we need to develop a more globally uniform curriculum with resp...

INTRODUCTION Melatonin, secreted by the pineal gland during the night phase, is a regulator of the biological clock and sleep tendency. Totally blind subjects frequently report severe, periodic sleep problems, with 50%-75% of cases displaying non-24-hour sleep-wake disorder (N24HSWD) due to inability to synchronize with the environmental day-night cycle. Melatonin immediate-release preparations...

Peptide-recognition modules (PRMs) are used throughout biology to mediate protein-protein interactions, and many PRMs are members of large protein domain families. Recent genome-wide measurements describe networks of peptide-PRM interactions. In these networks, very similar PRMs recognize distinct sets of peptides, raising the question of how peptide-recognition specificity is achieved using si...

Pairs of endothelial cells on adhesive micropatterns rotate persistently, but pairs of fibroblasts do not; coherent rotation is present in normal mammary acini and kidney cells but absent in cancerous cells. Why? To answer this question, we develop a computational model of pairs of mammalian cells on adhesive micropatterns using a phase field method and study the conditions under which persiste...

We present the Predicted Relevance Model (PRM): it allows moving from binary evaluation measures that reflect a single assessor’s judgments, towards graded measures that represent the relevance towards random users.

As the importance and complexity of medical device software continues to increase there is growing demand for effective process assessment and improvement in this domain. To address this need the Medi SPICE process assessment and improvement model is being developed. Regulatory compliance is both an important and challenging aspect of medical device software development. Particularly as new reg...

In this paper, an improved probabilistic roadmap (IPRM) algorithm is proposed to solve the energy consumption problem of multi-unmanned aerial vehicle (UAV) path planning with angle. Firstly, in order simulate real terrain environment, a mathematical model was established; secondly, then, sampling space (PRM) optimized make obtained more explicit and improve utilization rate time; third-order B...