A neutral mononuclear Fe(II) complex with spin crossover (SCO) properties, Fe2(SCN)2 (1) (L = 2-(2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline), was solvothermally synthesized. It displays a new example of two-step SCO with Tc1↓ = 250 K, Tc1↑ = 260 K and Tc2 = 295 K.

Twenty-four patients with stable angina were evaluated in a 14 week crossover trial. A single-blind placebo period (baseline 1) was followed by two double-blind periods evaluating maximum tolerated doses of diltiazem (up to 360 mg daily) vs placebo. Over the next 1 to 4 weeks, propranolol was started and increased until clinically documented beta-blockade was achieved (baseline 2). The final ph...

1. a,-Adrenoceptor-mediated vasoconstriction was studied before and during propranolol therapy in eight normal renin essential hypertensive patients; four were known ‘responders’ and four, age-matched ‘non-responders’ to previous p-receptor blocker monotherapy. Plasma renin activity, plasma adrenaline and noradrenaline concentrations as well as forearm blood flow were measured before and during...

The aims of this study were to develop a transdermal patch for selective controlled delivery of the active S-enantiomer from racemic propranolol, and to evaluate its performance in vivo using Wistar rats. A molecularly imprinted polymer (MIP) thin-layer composited cellulose membrane with selectivity for S-propranolol was employed as the enantioselective-controlled release system. The effect of ...

BACKGROUND Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas. METHODS In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a "hemangioma ...

osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (sns) and bone metabolism. leptin has been shown to regulate bone formation and bone resorption via the sns. however, the effect of sns on leptin signaling has not been clearly understood. in the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

PURPOSE Oral propranolol has become a promising treatment of capillary hemangiomas (CHs) despite concerns of side effects associated with systemic beta-blockers. The objective of this study was to investigate the distribution of propranolol in periocular tissues and in plasma after topical application of propranolol as compared with intravenous and oral administration of propranolol. METHODS ...