نتایج جستجو برای: protective antigens
تعداد نتایج: 225132 فیلتر نتایج به سال:
Antibody Responses to Immunizations in Children with Type I Diabetes Mellitus: a Case-Control Study.
Type I diabetes mellitus (DM) has been associated with abnormalities of T cells. Our objective was to assess whether antibody responses to T-cell-dependent and -independent antigens in children with DM are lower than those of children without DM. We performed a case-control study matching children with DM to children without DM by age and by assessing antibody levels to pneumococcal serotypes, ...
Knowledge of clinically targetable tumor antigens is becoming vital for broader design and utility therapeutic cancer vaccines. This information obtained reliably by directly interrogating the MHC-I presented peptide ligands, immunopeptidome, with state-of-the-art mass spectrometry. Our manuscript describes direct identification novel an aggressive triple-negative breast model. Immunopeptidome ...
BACKGROUND Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identified by seroepidemiological studies of individuals living in P. vivax-endemic areas, and is an important strategy given the limited ability to culture...
Reverse vaccinology (RV) is a computer-aided approach for vaccine development that identifies subset of pathogen proteins as protective antigens (PAgs) or potential candidates. Machine learning (ML)-based RV promising, but requires dataset PAgs (positives) and non-protective protein sequences (negatives). This study aimed to create an ML dataset, VPAgs-Dataset4ML, predict viral based on obtaine...
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has proved challenging; for tuberculosis and malaria, many of the antigens targeted by protective T cells are not known. Here, we report a novel approac...
In the search for a leishmaniasis vaccine, extensive studies of cutaneous leishmaniasis have been carried out. Investigations in this regard with the visceral form are limited. As an initial step in the identification of the protective molecules, leishmanial antigens extracted from the membranes of Leishmania donovani promastigotes, alone or in association with liposomes, were evaluated for the...
Leishmaniasis affects 12 million people but there are no vaccines in routine use. Recently, we used DNA vaccination in a susceptible BALB/c high-dose model of infection to screen 100 novel Leishmania major genes as vaccine candidates. In addition to finding novel protective antigens, we identified several antigens that reproducibly exacerbated disease. Here we examined the immune response to tw...
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