Uromodulin is a protein which is produced by the tubular cells of the thick ascending limb in the kidneys and the creatinine to uromodulin ratio in serum recently has attracted interest as a marker of kidney disease. Whether this ratio also is associated with cardiovascular event risk is unknown. This article provides additional data on the association of the creatinine to uromodulin ratio with...

Random urine samples of 352 children in the age group of 5-12 yrs were studied for urinary calcium-creatinine ratio (Uca/Ucr mg/mg). None had any predisposing factor for secondary hypercalciuria. Calcium and creatinine both were estimated by colorimetric method. We observed that Uca/Ucr in the general pediatric population was skewed, the pattern was similar to that described in western children...

et al., 1967; Zorab et al., 1970). Allison, Walker, and Smith (1966) showed that the ratio of total hydroxyproline to creatinine in a 24-hour collection of urine gives more consistent results than measurement of hydroxyproline alone, an observation which has been extended to random samples of urine collected during waking hours (Howells, Wharton, and McCance, 1967; Younoszai et al., 1969). Whar...

Treatment c Optimize glucose control to reduce the risk or slow the progression of diabetic kidney disease. A c Optimize blood pressure control to reduce the risk or slow the progression of diabetic kidney disease. A c For people with nondialysis-dependent diabetic kidney disease, dietary protein intake should be approximately 0.8 g/kg body weight per day (the recommended daily allowance). For ...