To downregulate cell signaling, eukaryotes modify plasma membrane receptors by ubiquitination (cargo) and deliver them via vesicles to the endosomal surfaces. Once at this location, cargo is delivered lysosomal lumen, where they are proteolyzed. The ubiquitin-binding protein TOM1 sorts through recognition of ubiquitin moieties its VHS GAT domains. phosphoinositide phosphatidylinositol 5-phospha...

A brain-enriched multi-domain scaffolding protein, neurobeachin has been identified as a candidate gene for autism patients. Mutations in the synaptic adhesion protein cell adhesion molecule 1 (CADM1) are also associated with autism spectrum disorder, a neurodevelopmental disorder of uncertain molecular origin. Potential roles of neurobeachin and CADM1 have been suggested to a function of vesic...

Following invasion of human red blood cells (RBCs) by the malaria parasite, Plasmodium falciparum, a remarkable process of remodeling occurs in the host cell mediated by trafficking of several hundred effector proteins to the RBC compartment. The exported virulence protein, P falciparum erythrocyte membrane protein 1 (PfEMP1), is responsible for cytoadherence of infected cells to host endotheli...