A high-intensity continuous-wave (CW) radio frequency quadrupole (RFQ) accelerator is designed for boron neutron capture therapy. The transmission efficiency of a 20-mA proton beam accelerated from 30 keV to 2.5 MeV can reach 98.7% at an operating 200 MHz. dynamics have good tolerance errors. By comparing the high-frequency parameters quadrilateral and octagonal RFQ cross sections, structure fo...

In an experiment performed with a high-intensity and high-energy laser system, $\ensuremath{\alpha}$-particle production in proton-boron reaction by using laser-driven proton beam was measured. $\ensuremath{\alpha}$ particles were observed from the front also rear side, even after 2-mm-thick boron target. The data obtained this have been analyzed sequence of numerical simulations. simulations c...

This review covers the application of cycloaddition reactions in forming the boron-containing compounds such as symmetric star-shaped boron-enriched dendritic molecules, nano-structured boron materials and aromatic boronic esters. The resulting boron compounds are potentially important reagents for both materials science and medical applications such as in boron neutron capture therapy (BNCT) i...

We report in vitro and in vivo evaluation of a newly designed trifunctional theranostic agent for targeting solid tumors. This agent combines a dendritic wedge with high boron content for boron neutron capture therapy or boron MRI, a monomethine cyanine dye for visible-light fluorescent imaging, and an integrin ligand for efficient tumor targeting. We report photophysical properties of the new ...

Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy tissue. However, BNCT in practice is still limited due to the lack of boron-containing compounds that selective...

Background: The present study aimed to investigate the equivalent dose in vital organs, including heart and lung, due to secondary particles produced during breast proton therapy. Materials and Methods: The numerical ORNL female-phantom was improved and simulated using the Monte Carlo MCNPX code. The depth-dose profile of proton beams with different energies was simulated. The proper energy ran...

One of the radiotherapy has boron neutron capture therapy (BNCT). They may make it easier to kill tumor cells with BNCT. In BNCT, it is important for boron agents, which have high selectively and high accumulation, to be introduced into tumor cells. To date, the main boron compounds used by the clinical study are sodium mercaptododecaborate (BSH) and pboronophenylalanine (BPA). But, there are n...