Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria. Since drug development is lengthy and expensive, a drug repurposing strategy offers an attractive fast-track approach to speed up the process. A ...

Natural products from plants have been used since ancestral times to treat a wide variety of diseases worldwide. Plants of the genus Salvia (Sage) have been reported to be used for the prevention and treatment of various diseases and ailments. In particular, some Salvia species have been used in traditional medicine to treat diseases caused by protozoan parasites of the genera Trypanosoma, Leis...

Pathogens induce several changes in the host cell signaling and trafficking mechanisms in order to evade and manipulate the immune response. One prominent pathogen-mediated change is the formation of lipid-rich organelles, termed lipid bodies (LBs) or lipid droplets, in the host cell cytoplasm. Protozoan parasites, which contribute expressively to the burden of infectious diseases worldwide, ar...

The filthy breeding habits, feeding mechanisms, and indiscriminate travel between filth and food make some groups of synanthropic insects such as nonbiting flies and cockroaches efficient vectors of human enteric protozoan parasites. Twenty-one species of filth flies have been listed by regulatory agencies concerned with sanitation and public health as causative agents of gastrointestinal disea...

conclusions rodents play an important role in the transfer of zoonotic parasite diseases, especially those that live near human habitats. control of rodent population in the city should be considered to decrease risk of transmission. results all studied rodents were infected at least by one parasite. the collected parasites included: three species of cestodes, eight species of nematodes, one sp...

Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of the genus Leishmania. It major health problem in many tropical and subtropical regions world can produce three different clinical manifestations, among which cutaneous leishmaniasis has higher incidence than other forms. There are no recognized reliable means chemoprophylaxis or vaccination against infections with f...

An undergraduate laboratory was developed as part of the Drugs for Neglected Diseases initiative’s Open Synthesis Network. This activity aimed to develop new compounds efficacious against visceral leishmaniasis. Students successfully synthesized, purified, and characterized ten different benzoxazole amides that were sent biological testing several protozoan parasites. Although all had poor L. d...

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness considered significant public health issue in developing countries. In addition, parasite resistance conventional medicinal treatment has increased recent years. Traditional medicine around world represents valuable source alternative for m...

PCR Detection of Babesia ovata from Cattle Reared in Japan and 1 Clinical Significance of Co-Infection with Theileria orientalis 2 3 Running title: Co-infection of B. ovata and T. orientalis in cattle 4 5 Thillaiampalam Sivakumar, Michihito Tagawa, Takeshi Yoshinari, Adrian P. Ybañez, 6 Ikuo Igarashi, Yuzuru Ikehara, Hiroshi Hata, Seiji Kondo, Kotaro Matsumoto, 7 Hisashi Inokuma, and Naoaki Yok...