We report 16 orthopaedic patients who had antibiotic-associated diarrhoea (pseudomembranous colitis) after operation. There was an association with the use of cephradine and with the prolongation of prophylaxis for more than three peri-operative doses. Five cases occurred as a cluster, suggesting that the causative agent, Clostridium difficile, may be infectious in some situations.

INTRODUCTION — Clostridium difficile associated disease (CDAD) is one of the most common hospitalacquired (nosocomial) infections, and is an increasingly frequent cause of morbidity and mortality among elderly hospitalized patients. C. difficile colonizes the human intestinal tract after the normal gut flora has been altered by antibiotic therapy and is the causative organism of antibiotic-asso...

This is a case report on a 35-year-old man with acute myelogenous leukemia who presented fever and intermittent mucoid loose stool to the emergency center. He had been taking voriconazole for invasive pulmonary aspergillosis. The flexible sigmoidoscopy was consistent with the diagnosis of pseudomembranous colitis.

1.1 Condition: Clostridium difficile infection (CDI). A diagnosis of CDI implies: a) laboratory detection of C. difficile toxins and/or toxigenic C. difficile in faeces, rectal swab or bowel contents PLUS b) relevant clinical manifestations: diarrhoea (usually defined as 3 or more loose stools in a 24 hour period) or, less commonly, ileus, toxic megacolon or pseudomembranous colitis (identified...

A new coronavirus infection poses a challenge to infectious disease specialists, health care administrators, and subspecialty physicians in the search for most eff ective treatment options. The past year has allowed us clarify main aspects of pathogenesis with focus on severe versions COVID-19 course. Most signifi cant is understand that course associated prolonged viremia T-cell lymphocyte def...

OBJECTIVES Clostridium difficile associated diarrhoea (CDAD) is a hospital acquired infection in which optimal methods for diagnosis and the scale of the problem in the community remain to be determined. In hospitalised patients with CDAD, we aimed to (i) study patients in whom the onset of diarrhoea was in the community and (ii) investigate the role of bedside flexible sigmoidoscopy in diagnos...

To cite: Abdulaziz S, AbouShala N, Al-Tarifi A, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-008786 DESCRIPTION A 49-year-old man was admitted to the intensive care unit (ICU) for septic shock secondary to Clostridium difficile infection (CDI) complicated with severe pseudomembranous colitis. His medical history was remarkable for glossectomy, prox...