We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly carboplatin + paclitaxel therapy resulted in the disappearance of tumor cells, but the patient die...

Objective. To determine whether immunological serum markers IFN-γ, IL-4, IL-17, IL-23, IL-6, TNF-α, and IL-10 are elevated or decreased in patients compared with healthy controls. Methods. A complete search of the literature on this topic within the past 30 years was conducted across seven databases. Seventeen studies including 768 individuals were identified. Differences in serum marker levels...

Psoriasis vulgaris is one of the common chronic skin diseases, which can affect any area of the skin, but scalp is one of the most frequently involved [1]. Although the head represents only 10% of the body's surface area, the consequences of scalp psoriasis are disproportionate to the area, as it can be seriously debilitating [2]. Scalp psoriasis is characterized by sharply demarcated erythemat...

Psoriasis vulgaris is a chronic, multisystem, genetic, noncontagious inflammatory disorder. Psoriasis limited to the glans penis is a rare presentation. We present two patients with penile involvement and absence of psoriatic lesions elsewhere on the body, which led to delay of diagnosis. Due to the specific localization, the treatment of choice was the calcineurin inhibitor pimecrolimus 1% crè...

OBJECTIVE To examine the reasons for resistance to treatment in cases of palmoplantar psoriasis, and also to compare the frequency of delayed-type hypersensitivity to common sensitizers with those cases of psoriasis without palmoplantar involvement. SUBJECTS AND METHODS One hundred and three patients with resistant palmoplantar psoriasis were examined for a possible drug reaction, fungal infe...

Retinoids are routinely used in dermatology for various clinical entities including acne vulgaris, rosacea, hypertrophic scars, strie distensae, psoriasis, disorders of dyskeratinization, cancer prevention and other chronic hyperkeratotic disorders. Oral acitretin therapy is effective in the treatment of psoriasis normalizing cellular differentiation and maturation but clinical side-effects are...

Sir, A 60‐year‐old Japanese man with a 30‐year history of psoriasis vulgaris was referred to our hospital. His previous treatments, including topical corticosteroids, Vitamin D analogs, narrowband ultraviolet B, and cyclosporine, demonstrated poor disease control. At his first visit, he presented with scaly erythematous plaques on his trunk, extremities, and scalp, with considerable itching. At...

Background: Psoriasis vulgaris is a recurrent chronic skin disorder signed by hyperproliferation and epidermal inflammation. One of the etiology psoriasis genetic factors related to polymorphism as disease susceptibility markers. This study was aimed analyze correlation TNF-α gene promoter region with vulgaris. Methods: An analytical observational cross-sectional design identify TNF-region po...