نتایج جستجو برای: pteridine reductase
تعداد نتایج: 44314 فیلتر نتایج به سال:
BACKGROUND Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate (Glucantime), the first line of treatment in Iran. This study was designed to determine whether the clinical responses (healing, or non-healing) were correlated with the susceptibility of Leishmania parasites to Glucantime. MET...
BACKGROUND Pteridine metabolic pathway is unusual features of Leishmania, which is necessary for the growth of parasite. Leishmania has evolved a complex and versatile pteridine salvage network which has the ability of scavenging a wide area of the conjugated and unconjugated pteridines especially folate and biopterin. In this study, we focus on the inhibition of ptr1 gene expression. METHODS...
Pteridine-metal complexes have recently been studied to mimic the environment and reactivity of the metal site of the enzymes and some of these have been characterized by X-ray crystallography, however, we have not been able to find any reference to gold(III) complexes with lumazine (pteridine-2,4(1H,3H)dione) ligands. The study of these complexes may be of interest due to the well-established ...
Pteridine derivatives have been shown to interfere with xanthine and guanine metabolism in vitro. 2-Amino-4-hydroxy-6-formylpteridine (l-3) and 2-amino-4-hydroxy-6-hydroxymethylpteridine (3) have been demonstrated to be potent inhibitors of xanthine oxidase in vitro. More recently, it has been observed that crude folic acid (4) and 6-formylpteridine (5) are inhibitors of guanase in vitro. Furth...
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