Objective: to determine the clinical effect of subconjunctival injection of bevacizumab in regression or halting growth in patients with recurrent pterygium. Method and materials: The study was an off-label; 2-dosing, interventional case series involving 20 patients with recurrent pterygium. They received subconjunctival bevacizumab (0.2ml/ 2.5mg). vascularity and thickness of Pterygium was gra...

Pterygium is a potentially vision-threatening fibrovascular lesion originating from the conjunctiva that often extends on the corneal surface. Although it has been extensively studied, its pathogenesis has yet to be fully elucidated. Recent evidence on molecular genetic abnormalities in pterygium suggested neoplastic changes of limbal stem cells potentially associated with exposure to ultraviol...

AIM To evaluate long term complications after pterygium excision with mitomycin C (MMC) application. DESIGN Prospective non-comparative interventional case series. PARTICIPANTS Ninety nine patients who underwent pterygium surgery and participated in a controlled study for efficacy of MMC for pterygium surgery between 1989 and 1994. METHODS Patients who were located and agreed to come for ...

Purpose: To evaluate blood vitamin D level in patients with pterygium. Methods: This prospective study, compared 58 eyes of 58 healthy individuals (control group) with 63 eyes of 63 patients with pterygium (study group). Subjects were stratified by time spent indoors or outdoors. Participants were given comprehensive ophthalmic examinations; blood 25-hydroxyvitamin D (nmol/L) was assayed. R...

BACKGROUND The aim of this study was to determine prolidase activity in conjunctival tissue and its relationship with pterygium. MATERIAL AND METHODS Prolidase activity was measured in 23 pterygium and 25 healthy conjunctival tissues and the 2 groups were compared. RESULTS Prolidase enzyme activity could not be measured in either the healthy conjunctival or in pterygium tissues. The mean se...

Pterygium is an abnormal overgrowth of the conjunctiva onto the cornea. Surgical management is the choice of treatment when persistent discomfort, visual distortion, and restricted ocular motility bothers patient’s life.1 Although an easy procedure, the main problem with the surgical excision of the pterygium is the recurrence rate, which can be as high as 30 to 82% (1-3). Recurrence is usually...

In the 1975-2004 period, 130 cases of pterygium were estimated, 83 males and 47 females, on a small island Rab. Island Rab is located in the north part of the Adriatic sea, which has very high index of sun radiation. Pterygium is usually histopathologically defined as a hyperplasia of conjunctival tissue, elastoid degeneration of subepithelieum and fragmentation of Bowman's membrane. Our histop...

Abstract Introduction: The aim of this study was to clinically evaluate lid margin abnormality, meibomian glands expression and tear function changes in patients with primary pterygium. Methods: Fifty normal 50 pterygia participants without other ocular pathologies were randomly selected from who attended an ophthalmology visit. gland expression, break-up time, Schirmer's test results surface d...

The expression of growth factors in ophthalmic pterygium and phenotypically normal conjunctiva was examined and correlated with the clinical findings. Fifteen specimens of ophthalmic pterygia and 8 specimens of phenotypically normal conjunctiva were examined. Total RNA was extracted from all specimens and mRNA levels for transforming growth factor (TGFB1), vascular endothelial growth factor (VE...