Neuropathic pain treatment remains a challenge because pathomechanism is not fully understood. It is believed that glial activation and increased spinal nociceptive factors are crucial for neuropathy. We investigated the effect of parthenolide (PTL) on the chronic constriction injury to the sciatic nerve (CCI)-induced neuropathy in rat. We analyzed spinal changes in glial markers and M1 and M2 ...

Dynamic pass-transistor logic (PTL), which combines pass-transistor logic with dynamic logic, is proposed for high-performance VLSI circuit design. The dynamic PTL holds the merits of fast evaluation characteristics as dynamic logic. Moreover, because a pre-charged scheme solves the weak logic ‘high’ problem of a static PTL, an additional level restoration circuit is not needed. An 8-bit multip...

In this work, single-phase (liquid water) and two-phase water gaseous oxygen) 3D-CFD flow analysis of the anode a high pressure PEM electrolysis cell was conducted. simulation models side porous transport layer electrolyzer were created for analysis. For geometrical modelling PTL, two approaches used: (a) exact geometry (b) simplified using porosity model. Before conducting simulations, model v...

Accurate diagnosis of stable angina is of paramount importance, and where possible, this should be based on clinical history. In cases of uncertainty, the National Institute for Health and Care Excellence (NICE) provides a framework for assisting diagnosis based on pre-test likelihood (PTL) of coronary artery disease. Functional testing such as stress echocardiography (SE) is recommended as a f...

We display the power Topp-Leone (PTL) distribution with two parameters. The following major features of PTL are investigated: quantile measurements, certain moment’s measures, residual life function, and entropy measure. Maximum likelihood, least squares, Cramer von Mises, weighted squares approaches used to estimate A numerical illustration is prepared compare behavior achieved estimates. Data...

OBJECTIVE Visfatin, a novel adipokine originally discovered as a pre-B-cell colony enhancing factor, is expressed by amniotic epithelium, cytotrophoblast, and decidua and is over-expressed when fetal membranes are exposed to mechanical stress and/or pro-inflammatory stimuli. Visfatin expression by fetal membranes is dramatically up-regulated after normal spontaneous labor. The aims of this stud...

Preterm birth remains the leading cause of neonatal mortality and morbidity worldwide. There are currently few effective therapies and therefore an urgent need for novel treatments. Although there is much focus on trying to alter gestation of delivery, the primary aim of preterm birth prevention therapies should be to reduce prematurity related mortality and morbidity. Given the link between in...

Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (LPS) from different bacteria can be used to independently or mutually activate Jun N-terminal kinase (JNK)/AP1- or NF-κB-driven inflammatory pathways that lead to PTL. Previous studies using Salmonella abortus LPS, which activates both JNK/AP-1 and NF-κB, showed that selective inhibition of NF-κB...

BACKGROUND Preterm labor (PTL) is one of the main causes of neonatal mortality and morbidity. PTL leads to serious complications especially in the gestational age prior to 24-26 weeks. The aim of this study was to investigate the effect of glyceryl trinitrate (GTN) patch on the treatment and complications of PTL. METHODS In this clinical trial, 84 singleton pregnant women with gestational age...

PtlH is an essential component of the Ptl system, the type IV transporter responsible for secretion of pertussis toxin (PT) across the outer membrane of Bordetella pertussis. The nine Ptl proteins are believed to interact to form a membrane-spanning apparatus through which the toxin is secreted. In this study, we monitored the subcellular localization of PtlH in strains of B. pertussis lacking ...