نتایج جستجو برای: pttg1
تعداد نتایج: 301 فیلتر نتایج به سال:
INTRODUCTION AND OBJECTIVE The ability to predict recurrence of pituitary adenoma (PA) after surgery may be helpful to determine follow-up frequency and the need for adjuvant treatment. The purpose of this study was to assess the prognostic capacity of pituitary tumor transforming gene (PTTG), insulin-like growth factor 1 receptor (IGF1R), and Ki-67. MATERIALS AND METHODS In this retrospectiv...
OBJECTIVE Pituitary tumor transforming gene (PTTG) is an important paracrine growth factor involved in early lactotrope transformation and early onset of angiogenesis in pituitary hyperplasia. Emerging evidences have shown that PTTG expression may contribute to the etiology of pituitary adenomas; but individually published studies showed inconclusive results. This meta-analysis aimed to derive ...
Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular tr...
Aneuploidy is frequent in cancers. Recently it was found that pituitary tumor transforming gene (PTTG; also called Pds1p or securin) is overexpressed in many different tumors. Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that primarily infects CD4+ T lymphocytes and causes adult T-cell leukemia. Here, we report that overexpression of human PTTG cooperated with the HTLV-I Tax onco...
The PTTG1-binding factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a protooncogene. High PBF expression is independently associated with poor prognosis and lower disease-specific survival in human thyroid cancer. However, the precise role of PBF in thyroid tumorigenesis is unclear. Here, we present extensive evidence demonstrating that PB...
and expansion of cancer stem cell population Chang-Hwan Yoon, Min-Jung Kim, Hyejin Lee, Rae-Kwon Kim, Eun-Jung Lim, Ki-Chun Yoo, Ga-Haeng Lee, Yan-Hong Cui, Yeong Seok Oh, Myung Chan Gye, Young Yiul Lee, In-Chul Park, Sungkwan An, Sang-Gu Hwang, Myung-Jin Park, Yongjoon Suh, and Su-Jae Lee Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea...
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