This study aimed to evaluate the feasibility and utility of using motorized pullback of the pressure guidewire to provide a graphic assessment and prediction of the benefits of coronary intervention. Fractional flow reserve (FFR) measurements were performed with motorized pullback imaging in 20 patients who underwent successful percutaneous coronary intervention (PCI) of the left anterior desce...

Candida albicans is the most frequently encountered fungal pathogen in humans, capable of causing mucocutaneous and systemic infections in immunocompromised individuals. C. albicans virulence is influenced by multiple factors. Importantly, iron acquisition and avoidance of the immune oxidative burst are two critical barriers for survival in the host. Prior studies using whole genome microarray ...

Title: Ketogenic Diets as an Adjuvant Therapy in Glioblastoma (The KEATING Trial): Study Protocol for a Randomised Pilot Study Authors: Kirsty Martin-McGill ([email protected]) Anthony Marson ([email protected]) Catrin Tudur Smith ([email protected]) Michael Jenkinson ([email protected]) Version: 2 Date: 18 Aug 2017 Author’s response to reviews: Dear Dr Lehana ...

This paper shows how to describe the pullbacks of directed complete posets (dcpos) along geometric morphisms. This extends Joyal and Tierney’s original results on the pullbacks of suplattices. It is then shown how to treat every frame as a dcpo and so locale pullback is described in this way. Applications are given describing triquotient assignments in terms of internal dcpo maps, leading to pu...

Background Pressure recovery is the variable increase in lateral pressure downstream from a stenotic orifice. The magnitude and clinical significance of pressure recovery in aortic valve stenosis are poorly defined. Methods and Results We obtained high-fidelity pressure and velocity recordings in 11 patients with isolated significant aortic valve stenosis at the time of diagnostic cardiac cathe...

Adjusting conventional Chern–Simons theory to G2-manifolds, one describes G2-instantons on bundles over a certain class of 7-dimensional flat tori which fiber nontrivially over T , by a pullback argument. Moreover, if c2 6= 0, any (generic) deformation of the G2-structure away from such a fibred structure causes all instantons to vanish. A brief investigation in the general context of (conforma...

The intestinal Ca(2+) transport protein CaT1 has recently been shown to have the biophysical characteristics of the Ca(2+)-release activated Ca(2+) channel that refills internal Ca(2+) stores following agonist-elicited release. This finding highlights a hitherto unrecognized link between epithelial Ca(2+) transport and Ca(2+) signalling.

Catalase plays a key role as an antioxidant, protecting aerobic organisms from the toxic effects of hydrogen peroxide, and in some cases has been postulated to be a virulence factor. To help elucidate the function of catalase in Candida albicans, a single C. albicans-derived catalase gene, designated CAT1, was isolated and cloned. Degenerate PCR primers based on highly conserved areas of other ...