Pulmonary arterial hypertension is characterized by high pulmonary blood pressure, vascular remodeling and right ventricular hypertrophy. In the present study, we investigated whether genistein would prevent the development of low temperature-induced pulmonary hypertension in broilers. Hemodynamic parameters, vascular remodeling, the expression of endothelial nitric oxide and endothelin-1 conte...

Pulmonary hypertension is a heterogeneous hemodynamic and pathophysiological state that is observed in a number of clinical conditions, which have been divided into six diagnostic groups. Although the increase in pulmonary pressure observed in these clinical groups may be similar, underlying disease mechanisms, diagnostic methods, and prognostic and therapeutic consequences are completely diffe...

p s c l o a Pulmonary hypertension, whether caused by idiopathic pulmonary arterial hypertension or as a complication of an increasingly recognized number of primary disease states, is associated with significant mortality and morbidity (1,2). Diagnosing pulmonary hypertension, however, may be challenging (3). Symptoms can be nonspecific and may be attributed to the underlying disease, and unli...