Diffuse hemorrhage is a known but infrequent complication of amiodarone pulmonary toxicity and a cause of hemoptysis, with 12 cases reported up to now. Unlike other form of amiodarone pulmonary toxicity, early or very early1 onset seems to be common. It is thought to be mistaken for acute heart failure in many patients, due to similar clinical pattern and concomitant use of anti-aggregants or a...

Chemotherapy-induced lung toxicity can affect pulmonary parenchyma, pleura, airways, pulmonary vascular system, mediastinum or the neuromuscular system that is responsible for respiration. Chemotherapy-induced pulmonary toxicity is a diagnosis of exclusion. When the patients with malignancies develop pulmonary toxicity such as pneumonitis and distinguishing it from alternative diseases such as ...

Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor may be a possible solution to overcome these issues. We therefore developed lung surfactant mimetic and...

Pulmonary injury due to allergy (hypersensitivity) or direct drug toxicity has been described in association with a number of drugs. Nitrofurantoin3 and perhaps methotrexate* may cause a true hypersensitivity type of lung injury. Eosinophilia is often present and it has been postulated that antigen-antibody complexes are involved in triggering cellular damage. In contrast, interstitial pneurnon...

Background: Diazoxide is the main therapeutic agent for congenital hyperinsulinism. The drug is generally well tolerated; however, in this report severe adverse effects including heart failure (HF) and pulmonary hypertension (PH) in an infant are reported.Case report: A sixteen-day male infant with persistent hypoglycemia and with diagnosis of congenital hyperinsulinism underwent near total pan...

♦Corresponding Author: Maher Soliman, MD Oncology Department, Faculty of Medicine, Alexandria University, Alexandria 21526, Alexandria, Egypt Tel: (+2) 03-4848280 Fax: (+2) 03-4848280 E-mail: [email protected] Abstract Background: Radiation-induced lung toxicity is an important dose-limiting toxicity in lung cancer radiotherapy, for which there are no generally accepted predictive fa...

PURPOSE The purpose of this study was to compare leukemia-free survival (LFS) and other clinical outcomes in patients with acute myelogenous leukemia who underwent a myeloablative allogeneic stem cell transplant with and without total body irradiation (TBI). METHODS AND MATERIALS Adult patients with acute myelogenous leukemia undergoing myeloablative allogeneic stem cell transplant at Duke Un...