Novel oral regimens composed of new drugs with potent activity against Mycobacterium tuberculosis and no cross-resistance with existing agents are needed to shorten and simplify treatment for both drug-susceptible and drug-resistant tuberculosis. As part of a continuing effort to evaluate novel drug combinations for treatment-shortening potential in a murine model, we performed two long-term, r...

Chitosan coated alginate microcapsules were developed as oral sustained delivery carriers for anti tubercular drugs in order to improve patient compliance, to reduce dose/dosing frequency in the management of tuberculosis (TB), which otherwise demands prolonged chemotherapy. Alginate–chitosan microparticles encapsulating three frontline anti-tuberculosis drugs (ATDs), rifampicin, isoniazide and...

Introduction. Current therapeutic regimens with first-line antitubercular agents are associated to a high rate of adverse effects which could cause pronounced changes in collagen's contents and structure. Investigation of these changes is very important for optimization of antitubercular therapy and minimization of treatment-caused harm. The aim of present paper was to investigate potential eff...

OBJECTIVE To determine primary and acquired resistance to pyrazinamide in Mycobacterium tuberculosis strains isolated in sputum samples from patients with pulmonary tuberculosis. METHODS This was a prospective, descriptive study conducted between April and November of 2011 at a referral hospital for tuberculosis in the city of Recife, Brazil. Cultures, drug sensitivity tests, and tests of pyr...

three antituberculosis medications are investigated in this work consist of rifampicin, isoniazid and pyrazinamide. the ultra violet (uv) spectra of these compounds are overlapped, thus use of suitable chemometric methods are helpful for simultaneous spectrophotometric determination of them. a generalized version of net analyte signal standard addition method (gnassam) was used for determinatio...

Running head：Dysosmia related to pyrazinamide Keywords：Tuberculosis, drug-induced adverse effects, olfactory disturbance Word count：597 words

Abstract Mechanochemical milling of ethenzamide (ETZ), a nonsteroidal anti‐inflammatory drug, with substituted aromatic carboxylic acids as well anti‐tuberculosis drug pyrazinamide (PZA) resulted in the formation eutectics. Although large number cocrystals polymorphic are reported for ETZ, first time we have synthesized six eutectics including an instance drug‐drug eutectic system. Supramolecul...

BACKGROUND Tuberculosis is a common complication of HIV-1 infection, especially in developing countries. Practical and effective chemoprophylaxis regimens for HIV-1-related tuberculosis are needed. Our aim was to test the efficacy of isoniazid versus rifampicin with pyrazinamide for prevention of tuberculosis in HIV-1-positive individuals. METHODS We compared the efficacy of 6 months of isoni...

TO THE EDITOR—We read the metaanalysis by Bastos et al recently published in Clinical Infectious Diseases [1]. Because of our interest in the association of drug susceptibility testing (DST) results for firstand second-line drugs with treatment outcomes in patients with multidrugresistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis, we carefully read the entire article....