An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.

N-substituted pyrazole dialdehydes are shown to react with a tripyrrane under '3 + 1' conditions to give aza-analogues of the N-confused porphyrins; these novel porphyrinoids show borderline aromatic properties and readily afford organometallic derivatives with Ni(OAc)2 and Pd(OAc)2.

An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant an...

Pyrazolines, which are nitrogen including five-membered heterocyclic structures, have been used in the organic and pharmaceutical industries. This study aimed was to synthesize characterizes new series of 3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives. The pyrazoline compounds synthesized from chalcones hydrazine hydrate two steps. In first step, were 2-amino acetophenone various substituted ...

UNLABELLED In vitro antitumor evaluation of the synthesized 46 compounds of 3,5-diaryl-4,5-dihydropyrazoles against EAC cell lines and 3D QSAR study using pharmacophore and Comparative Molecular Field Analysis (CoMFA) methods were described. CoMFA derived QSAR model shows a good conventional squared correlation coefficient r2 and cross validated correlation coefficient r2cv 0.896 and 0.568 resp...

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee).

Two efficient and convenient procedures for the synthesis of 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3c]pyrazole-5-carbonitrile derivatives based on four-component reaction involving ethyl acetoacetate, phenylhydrazine, malononitrile, and various aromatic aldehydes using trichloroacetic acid or ceric sulfate as heterogeneous catalysts in excellent yields and short reaction times have ...

Objective: The significant drawbacks of chemotherapy are that it destroys healthy cells, resulting in adverse effects. Hence, there is a need to adopt new techniques develop cancer-specific chemicals target the molecular pathways non-toxic fashion. This study aims screen pyrazole-condensed heterocyclics for their anticancer activities and analyse enzyme inhibitory potentials EGFR, ALK, VEGFR TN...

Cancer is the second leading cause of death worldwide. There always a huge demand for novel anticancer. New series pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened their antitumor activity against breast cancer cell line (MCF-7). The results this investigation revealed that compounds 3 8 had significant anticancer MCF-7 with IC50 values 19.2 14.2...