Background: Pyrin domains (PYDs) mediate the assembly of inflammasome complexes, but PYD interaction modes are not well characterised. Results: Interaction sites were identified on the PYD of the inflammasome adaptor protein, ASC. Conclusion: ASC PYD has multiple binding sites allowing self-association and interaction with binding partners. Significance: Understanding molecular details of infla...

Familial Mediterranean Fever (FMF) is associated with mutation in the gene coding for pyrin which lead to accentuated innate immune responses involving the IL1 and probably Th1 pathways. We present a teenager who had FMF and Behçet disease and developed secondary amyloidosis. We hypothesized that anti-IL1 treatment would be beneficial for both controlling the disease activity and maintaining re...

Tämän taiteelliseen tohtorintutkintoon sisältyvän tutkielman aiheena on sinfonisen puhallinorkesterin historia, nykytilanne sekä ohjelmisto. Ohjelmiston kartoittamisen tuloksena olen koonnut liitteenä olevan teosluettelon keskeisestä eurooppalaisesta sinfonisesta puhallinorkesterimusiikista 1900-luvun alusta nykyaikaan. Etsiessäni ohjelmistoa Euroopan eri maista sain mahdollisuuden tutustua luk...