Thyroglobulin labeled with L-[U-‘*C]tyrosine was prepared, purified, and iodinated in order to investigate the fate of the 3-carbon fragment which remains when 2 iodotyrosine residues (18 carbon atoms) in thyroglobulin react with each other in the course of thyroid hormonogenesis to form 1 hormone residue (15 carbon atoms). Incubation of hog thyroid slices with L-[U-‘*C]tyrosine led to the form...

H-Phosphinic acid and pyruvic acid, both plausible prebiotic chemicals, react selectively in water to build structural complexity including amide bond formation under remarkably mild conditions and oxidative coupling of P(1) compounds to condensed pyrophosphorus compounds.

Phenyl pyruvic oligophrenia, first described by Foiling (1934), is a well-defined clinical entity associated with an inborn metabolic defect involving the amino-acid phenylalanine. The patient excretes an excessive amount (above 1 gramme per day) of phenyl pyruvic acid and is invariably an idiot or an imbecile. The incidence in general population according to Jervis (Jervis, 1939) is 4 in 100,0...

Background: Non-invasive tumor characterization and monitoring are among the key goals of medical imaging. Using hyperpolarized 13C-labelled metabolic probes fast metabolic pathways can be probed in real-time, providing new opportunities for tumor characterization. In this in vitro study, we investigated whether measurement of apparent diffusion coefficient (ADC) measurements and magnetic reson...