This study was concerned with changes in the auditory canal and its associated structures in rats as affected by aging and by oral administration of tià ̄s(p-aminophenyl)carbonium pamoate (TACP). Multiple sections of tissue blocks from the auditory canal area were reviewed in control and treated animals of both sexes, and of varying ages up to 18 months. Tumors were found in the auditory canal g...

Accepted: 05/09/2013 Abstract Twenty four lions of Nandankanan Zoo were studied for prevalence of nematode eggs by faecal sample analysis and the prevalence rate was found to be 70%. For evaluation of anthelmintics, 20 lions were considered and were divided into four groups according to the drug administered and each group consisted of five animals. The lions were administered pyrantel pamoate ...

Received: Revised: Accepted: 2013–11–17 2014–02–28 2014–03–04 The study was conducted to determine the infection rate of helminths in peafowls and to evaluate the comparative efficacy of two broad spectrum anthelmintics. For this purpose, fecal samples of 87 different breeds of peafowls were collected and tested for the presence of helminths. Fecal samples were examined by direct smear and cent...

Olanzapine long-acting injection (OLAI) is a crystalline salt composed of olanzapine and pamoic acid, which permits a depot intramuscular formulation of olanzapine. The half-life of olanzapine pamoate is 30 days, and its steady state is reached approximately at 12 weeks. Oral supplementation of olanzapine is not required during OLAI initiation, according to Eli Lilly recommendations, although a...

Tnis(p-aminophenyl)carbonium pamoate (2 lots) was administered as drug-diet for an 18-month period to male and female albino rats (Holtzman source) . Both lots of compound were prepared from the chloride salt, one from an approximately 98.6 % pure sample, and the other from a highly purified and apparently homogenous sample. There was a marked increase in total tumor incidence in the treated fe...

Cellular senescence is considered as a tumor suppressive mechanism. Recent evidence indicates however that senescent cells secrete various growth factors and cytokines, some of which may paradoxically promote cancer progression. This phenomenon termed senescence-associated secretory phenotype (SASP) must be inhibited in order for anti-proliferative agents to be effective. The present study was ...

Oesophagostomum bifurcum has recently been recognized as a common parasite of man in northern Togo and in Ghana. In a preliminary trial several anthelmintics were evaluated in the treatment of mixed Oesophagostomum and hookworm infections. Diagnosis was based on faecal culture, since the eggs of Oesophagostomum and hookworm cannot be distinguished morphologically. Of the anthelmintics tested, a...