Q1: Au: Please confirm this is the correct author for correspondence Q2: Au: Edit OK? Or is text missing? “comprise” is not correct here—there needs to be more than one item or idea, i.e., the concept database comprises the concept-entity database and something else. Q3: Au: Edit for 2nd author name correct? Q4: Au: Is this the correct number of subcomponents? Q5: Au: Is 50% correct here? In al...

Here, we report two novel GUCA1A (the gene for guanylate cyclase activating protein 1) mutations identified in unrelated Spanish families affected by autosomal dominant retinal degeneration (adRD) with cone and rod involvement. All patients from a three-generation adRD pedigree underwent detailed ophthalmic evaluation. Total genome scan using single-nucleotide polymorphisms and then the linkage...

We estimate a spatially explicit model of the forest clearance process among smallholder farmers in an agricultural frontier of southern Mexico. Our analysis takes as its point of departure a simple utility-maximising model that suggests many possible determinants of deforestation in an economic environment characterised by missing or thin markets. Hypotheses from the model are tested on a data...

The q13 to q15 region of human chromosome 12 is frequently and consistently rearranged in malignant and benign adipose tissue tumors as well as benign tumors of smooth muscle and salivary glands. A reciprocal translocation, (12;16) (q13;p11), is characteristic of the myxoid subtype of liposarcoma, whereas translocations within 12q13-14 are frequently observed in benign lipomas. We are using pul...

AIM To assess and compare the knowledge of basic life support (BLS) among third, fourth and fifth (III, IV and V) year Bachelor of Dental Surgery (BDS) clinical students, dental interns, postgraduate students and Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) faculty of Panineeya Institute of Dental Sciences and Hospital, Hyderabad, India. MATERIALS AND METHODS A BLS ques...

Using a genomics-based approach for screening orphan G-protein-coupled receptors, we have identified and cloned a novel high-affinity, melanin-concentrating hormone (MCH) receptor. This receptor, named S643b, displays the greatest overall identity (32%) with the previously reported human SLC-1 receptor (MCH1) and to a lesser extent with the somatostatin receptor subtypes. The gene encoding the ...

The expansion of trade in pre-industrial Europe led to a transformation of agriculture. It induced specialization to exploit comparative advantage as well as a restructuring of the process of production, with manorial agriculture giving way to an agriculture of family farms. Technological progress was not itself a driving force, but rather a consequence of this transformation. Merchants and urb...